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Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: Improved catalyst efficiency by ligand-tuning

Yabu, K and Masumoto, S and Kanai, M and Curran, DP and Shibasaki, M (2002) Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: Improved catalyst efficiency by ligand-tuning. Tetrahedron Letters, 43 (16). 2923 - 2926. ISSN 0040-4039

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Abstract

Enantioselective catalyst efficiency for the synthesis of the camptothecin family was improved through ligand-tuning. Key intermediates of two convergent syntheses of camptothecin (Curran's intermediate and Corey's intermediate) were obtained in up to 10 g scale through the catalytic enantioselective cyanosilylation of ketones. © 2002 Elsevier Science Ltd. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Yabu, K
Masumoto, S
Kanai, M
Curran, DPcurran@pitt.eduCURRAN
Shibasaki, M
Date: 15 April 2002
Date Type: Publication
Journal or Publication Title: Tetrahedron Letters
Volume: 43
Number: 16
Page Range: 2923 - 2926
DOI or Unique Handle: 10.1016/s0040-4039(02)00451-3
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0040-4039
Date Deposited: 12 Feb 2014 23:45
Last Modified: 02 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/20499

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