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Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis

Zhang, W and Curran, DP and Chen, CHT (2002) Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis. Tetrahedron, 58 (20). 3871 - 3875. ISSN 0040-4020

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Abstract

A general fluorous thiol quenching method is introduced. Excess α-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel. © 2002 Elsevier Science Ltd. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zhang, W
Curran, DPcurran@pitt.eduCURRAN
Chen, CHT
Date: 13 May 2002
Date Type: Publication
Journal or Publication Title: Tetrahedron
Volume: 58
Number: 20
Page Range: 3871 - 3875
DOI or Unique Handle: 10.1016/s0040-4020(02)00209-0
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0040-4020
Date Deposited: 13 Feb 2014 18:55
Last Modified: 02 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/20507

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