Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis

Zhang, W and Curran, DP and Chen, CHT (2002) Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis. Tetrahedron, 58 (20). 3871 - 3875. ISSN 0040-4020

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Abstract

A general fluorous thiol quenching method is introduced. Excess α-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel. © 2002 Elsevier Science Ltd. All rights reserved.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Zhang, W Curran, DP curran@pitt.edu CURRAN Chen, CHT
Date:	13 May 2002
Date Type:	Publication
Journal or Publication Title:	Tetrahedron
Volume:	58
Number:	20
Page Range:	3871 - 3875
DOI or Unique Handle:	10.1016/s0040-4020(02)00209-0
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0040-4020
Date Deposited:	13 Feb 2014 18:55
Last Modified:	02 Feb 2019 15:58
URI:	http://d-scholarship.pitt.edu/id/eprint/20507

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