Zhang, W and Curran, DP and Chen, CHT
(2002)
Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis.
Tetrahedron, 58 (20).
3871 - 3875.
ISSN 0040-4020
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Abstract
A general fluorous thiol quenching method is introduced. Excess α-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel. © 2002 Elsevier Science Ltd. All rights reserved.
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