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Fluorous techniques for the synthesis and separation of organic molecules

Curran, D and Lee, ZR (2001) Fluorous techniques for the synthesis and separation of organic molecules. Green Chemistry, 3 (1). ISSN 1463-9262

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Abstract

By directly addressing the separation problems inherent in the synthesis of small organic molecules, fluorous techniques provide an array of powerful solutions that span the discipline of organic synthesis from large-scale chemical processes through traditional fine synthesis to modern chemical discovery by combinatorial methods. The above Table summaries the four main fluorous methods outlined in this overview and compares and contrasts them. Fluorous methods are attractive and easy to apply because the experimental techniques (solution phase reactions, liquid-liquid extractions, solid phase extractions) are familiar to practicing organic chemists. What differs from standard organic techniques are the fluorous components that are used. The application of fluorous techniques has been limited to a few specialized laboratories due to the lack of availability of fluorous reagents, reactants, tags, solvents, silica, etc. However, a new company, Fluorous Technologies (see box) intends to change this by providing laboratories worldwide with both the materials and the expertise that are needed to integrate fluorous methods into their ongoing discovery and production projects.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Curran, Dcurran@pitt.eduCURRAN
Lee, ZR
Date: 1 December 2001
Date Type: Publication
Journal or Publication Title: Green Chemistry
Volume: 3
Number: 1
DOI or Unique Handle: 10.1039/b100266j
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1463-9262
Article Type: Review
Date Deposited: 13 Feb 2014 18:54
Last Modified: 15 Oct 2017 07:55
URI: http://d-scholarship.pitt.edu/id/eprint/20508

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