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Combinatorial chemistry and contemporary pharmacology

Lazo, JS and Wipf, P (2000) Combinatorial chemistry and contemporary pharmacology. Journal of Pharmacology and Experimental Therapeutics, 293 (3). 705 - 709. ISSN 0022-3565

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Abstract

Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high- throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lazo, JS
Wipf, Ppwipf@pitt.eduPWIPF
Date: 1 June 2000
Date Type: Publication
Journal or Publication Title: Journal of Pharmacology and Experimental Therapeutics
Volume: 293
Number: 3
Page Range: 705 - 709
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0022-3565
Article Type: Review
MeSH Headings: Combinatorial Chemistry Techniques; Peptide Library; Pharmacology
PubMed ID: 10869367
Date Deposited: 27 Feb 2014 16:51
Last Modified: 02 Feb 2019 15:56
URI: http://d-scholarship.pitt.edu/id/eprint/20625

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