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Cellular kinetics of perivascular MSC precursors

Chen, WCW and Park, TS and Murray, IR and Zimmerlin, L and Lazzari, L and Huard, J and Péault, B (2013) Cellular kinetics of perivascular MSC precursors. Stem Cells International.

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Abstract

Mesenchymal stem/stromal cells (MSCs) and MSC-like multipotent stem/progenitor cells have been widely investigated for regenerative medicine and deemed promising in clinical applications. In order to further improve MSC-based stem cell therapeutics, it is important to understand the cellular kinetics and functional roles of MSCs in the dynamic regenerative processes. However, due to the heterogeneous nature of typical MSC cultures, their native identity and anatomical localization in the body have remained unclear, making it difficult to decipher the existence of distinct cell subsets within the MSC entity. Recent studies have shown that several blood-vessel-derived precursor cell populations, purified by flow cytometry from multiple human organs, give rise to bona fide MSCs, suggesting that the vasculature serves as a systemic reservoir of MSC-like stem/progenitor cells. Using individually purified MSC-like precursor cell subsets, we and other researchers have been able to investigate the differential phenotypes and regenerative capacities of these contributing cellular constituents in the MSC pool. In this review, we will discuss the identification and characterization of perivascular MSC precursors, including pericytes and adventitial cells, and focus on their cellular kinetics: cell adhesion, migration, engraftment, homing, and intercellular cross-talk during tissue repair and regeneration. © 2013 William C. W. Chen et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chen, WCW
Park, TS
Murray, IR
Zimmerlin, L
Lazzari, L
Huard, J
Péault, B
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorPhinney, Donald GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Centers: Other Centers, Institutes, or Units > McGowan Institute for Regenerative Medicine
Other Centers, Institutes, or Units > Stem Cell Research Center
Date: 23 September 2013
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Stem Cells International
DOI or Unique Handle: 10.1155/2013/983059
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Refereed: Yes
Article Type: Review
Date Deposited: 31 Mar 2014 14:41
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/20796

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