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The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury

Kobayashi, T and Uehara, K and Ota, S and Tobita, K and Ambrosio, F and Cummins, JH and Terada, S and Fu, FH and Huard, J (2013) The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury. Journal of Applied Physiology, 114 (2). 262 - 273. ISSN 8750-7587

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Abstract

In summary, we have demonstrated that the administration of a high dose (300 mg·kg-1·day-1) of Los immediately after injury could accelerate muscle healing, but not when a humanequivalent dose, used for the treatment of hypertension (10 mg·kg -1·day-1), was administered immediately following injury. Interestingly, administering 10 mg·kg-1·day-1 of Los 3 or 7 days after skeletal muscle contusion injury could significantly enhance the structural and functional healing of skeletal muscle in mice. This study demonstrated that Los administered at a human-equivalent dosage concentration used to treat hypertension in humans can directly mediate the inhibition of MSTN and/or via the upregulation of FSTN, which then inhibits MSTN, or through a combination of both. This study suggests that the use of Los to expedite the muscle healing process could also be applied to other types of acute muscle injuries and may also be useful for the treatment of degenerative fibrotic muscle disorders. © 2013 the American Physiological Society.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kobayashi, T
Uehara, K
Ota, S
Tobita, Kkit3@pitt.eduKIT3
Ambrosio, Ffaa7@pitt.eduFAA7
Cummins, JH
Terada, S
Fu, FHffu@pitt.eduFFU
Huard, J
Centers: Other Centers, Institutes, Offices, or Units > Stem Cell Research Center
Date: 15 January 2013
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 114
Number: 2
Page Range: 262 - 273
DOI or Unique Handle: 10.1152/japplphysiol.00140.2011
Schools and Programs: School of Medicine > Developmental Biology
School of Medicine > Orthopaedic Surgery
School of Medicine > Physical Medicine and Rehabilitation
Refereed: Yes
ISSN: 8750-7587
PubMed ID: 23154994
Date Deposited: 31 Mar 2014 15:22
Last Modified: 03 Feb 2019 01:55
URI: http://d-scholarship.pitt.edu/id/eprint/20828

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