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Human blood-vessel-derived stem cells for tissue repair and regeneration

Chen, CW and Corselli, M and Péault, B and Huard, J (2012) Human blood-vessel-derived stem cells for tissue repair and regeneration. Journal of Biomedicine and Biotechnology, 2012. ISSN 1110-7243

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Multipotent stem/progenitor cells with similar developmental potentials have been independently identified from diverse human tissue/organ cultures. The increasing recognition of the vascular/perivascular origin of mesenchymal precursors suggested blood vessels being a systemic source of adult stem/progenitor cells. Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues. Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively. MECs and pericytes efficiently regenerate myofibers in injured and dystrophic skeletal muscles as well as improve cardiac function after myocardial infarction. The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined. Our recent finding that MECs and pericytes can be purified from cryogenically banked human primary muscle cell culture further indicates their potential applications in personalized regenerative medicine. Copyright 2012 Chien-Wen Chen et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Chen, CW
Corselli, M
Péault, B
Huard, J
ContributionContributors NameEmailPitt UsernameORCID
Centers: Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Other Centers, Institutes, Offices, or Units > Stem Cell Research Center
Date: 16 March 2012
Date Type: Publication
Journal or Publication Title: Journal of Biomedicine and Biotechnology
Volume: 2012
DOI or Unique Handle: 10.1155/2012/597439
Schools and Programs: School of Medicine > Orthopaedic Surgery
Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 1110-7243
Article Type: Review
Date Deposited: 04 Apr 2014 15:48
Last Modified: 29 Jan 2019 15:56


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