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Timing of the administration of suramin treatment after muscle injury

Nozaki, M and Ota, S and Terada, S and Li, Y and Uehara, K and Gharaibeh, B and Fu, FH and Huard, J (2012) Timing of the administration of suramin treatment after muscle injury. Muscle and Nerve, 46 (1). 70 - 79. ISSN 0148-639X

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Introduction: It has been reported that suramin treatment can improve muscle healing; however, details about optimizing the dosing requirements remain unclear. The purpose of this study was to determine the optimal timing of suramin administration and investigate the effects it had on the expression of myostatin, follistatin, and muscle vascularity after muscle injury. Methods: Contusion injured muscles of mice were treated with suramin at 1, 2, or 3 weeks post-injury and evaluated histologically and physiologically at 1, 2, and 10 days after injection. Results: Suramin treatment initiated at 2 weeks post-injury was observed to promote muscle regeneration and muscle strength, and to decrease fibrosis. Suramin reduced myostatin expression and increased follistatin expression and vascularity in injured skeletal muscle. Conclusions: Suramin's positive effect on muscle regeneration is thought to be due to its enhancement of follistatin expression which increases neoangiogenesis and inhibits myostatin's promotion of fibrosis. © 2012 Wiley Periodicals, Inc.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Nozaki, M
Ota, S
Terada, S
Li, Y
Uehara, K
Gharaibeh, Bburhan@pitt.eduBURHAN0000-0002-5947-1232
Fu, FHffu@pitt.eduFFU
Huard, J
Centers: Other Centers, Institutes, Offices, or Units > Stem Cell Research Center
Date: 1 July 2012
Date Type: Publication
Journal or Publication Title: Muscle and Nerve
Volume: 46
Number: 1
Page Range: 70 - 79
DOI or Unique Handle: 10.1002/mus.23280
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
ISSN: 0148-639X
MeSH Headings: Animals; Antineoplastic Agents--administration & dosage; Antineoplastic Agents--therapeutic use; Contusions--drug therapy; Contusions--metabolism; Drug Administration Schedule; Fibroblasts--drug effects; Fibroblasts--metabolism; Fibrosis--metabolism; Follistatin--metabolism; Male; Mice; Muscle Strength--drug effects; Muscle, Skeletal--drug effects; Muscle, Skeletal--injuries; Muscle, Skeletal--metabolism; Suramin--administration & dosage; Suramin--therapeutic use; Wound Healing--drug effects
PubMed ID: 22644812
Date Deposited: 31 Mar 2014 15:33
Last Modified: 25 Jan 2019 23:55


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