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Effect of host sex and sex hormones on muscle-derived stem cell-mediated bone formation and defect healing

Meszaros, LB and Usas, A and Cooper, GM and Huard, J (2012) Effect of host sex and sex hormones on muscle-derived stem cell-mediated bone formation and defect healing. Tissue Engineering - Part A, 18 (17-18). 1751 - 1759. ISSN 1937-3341

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Abstract

Muscle-derived stem cells (MDSCs) are known to exhibit sexual dimorphism, by donor sex, of osteogenic, chondrogenic, and myogenic differentiation potential in vitro. Moreover, host sex differences in the myogenic capacity of MDSCs in vivo are also observed. This study investigated the role of host sex and host sex hormones in MDSC-mediated bone formation and healing. Using unaltered male, castrated male, unaltered female, and ovariectomized female mice, both MDSC-mediated ectopic bone formation and cranial defect healing were examined. Male hosts, whether unaltered or castrated, form significantly larger volumes of MDSC-mediated ectopic bone than female hosts (either unaltered or ovariectomized), and no differences in ectopic bone volume were found between hosts of the same sex. In a cranial defect healing model, similar results were found-unaltered and castrated male hosts display larger volumes of bone formed when compared with unaltered and ovariectomized female hosts. However, in this healing model, some volume differences were found between hosts of the same sex. In both models, these differences were attributed to varying rates of endochondral bone formation in male and female hosts. © Copyright 2012, Mary Ann Liebert, Inc.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Meszaros, LB
Usas, A
Cooper, GMgmc8@pitt.eduGMC8
Huard, J
Centers: Other Centers, Institutes, or Units > Stem Cell Research Center
Date: 1 September 2012
Date Type: Publication
Journal or Publication Title: Tissue Engineering - Part A
Volume: 18
Number: 17-18
Page Range: 1751 - 1759
DOI or Unique Handle: 10.1089/ten.tea.2011.0448
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
School of Medicine > Orthopaedic Surgery
School of Medicine > Pediatrics
School of Medicine > Physical Medicine and Rehabilitation
School of Medicine > Surgery
Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 1937-3341
MeSH Headings: Animals; Choristoma--pathology; Choristoma--radiography; Female; Gonadal Steroid Hormones--pharmacology; Image Processing, Computer-Assisted; Male; Mice; Mice, Inbred C57BL; Muscles--cytology; Osteogenesis--drug effects; Ovariectomy; Sex Characteristics; Skull--drug effects; Skull--pathology; Skull--radiography; Stem Cells--cytology; Stem Cells--drug effects; Stem Cells--metabolism; Tomography, X-Ray Computed; Wound Healing--drug effects
Other ID: NLM PMC3432905
PubMed Central ID: PMC3432905
PubMed ID: 22712541
Date Deposited: 04 Apr 2014 15:53
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/20850

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