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The effect of muscle loading on skeletal muscle regenerative potential: An update of current research findings relating to aging and neuromuscular pathology

Ambrosio, F and Kadi, F and Lexell, J and Kelley Fitzgerald, G and Boninger, ML and Huard, J (2009) The effect of muscle loading on skeletal muscle regenerative potential: An update of current research findings relating to aging and neuromuscular pathology. American Journal of Physical Medicine and Rehabilitation, 88 (2). 145 - 155. ISSN 0894-9115

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Abstract

Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist. Copyright © 2009 by Lippincott Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ambrosio, Ffaa7@pitt.eduFAA7
Kadi, F
Lexell, J
Kelley Fitzgerald, G
Boninger, MLboninger@pitt.eduBONINGER
Huard, J
Centers: Other Centers, Institutes, Offices, or Units > Stem Cell Research Center
Date: 1 January 2009
Date Type: Publication
Journal or Publication Title: American Journal of Physical Medicine and Rehabilitation
Volume: 88
Number: 2
Page Range: 145 - 155
DOI or Unique Handle: 10.1097/phm.0b013e3181951fc5
Schools and Programs: School of Medicine > Orthopaedic Surgery
School of Medicine > Physical Medicine and Rehabilitation
Refereed: Yes
ISSN: 0894-9115
Article Type: Review
MeSH Headings: Aging--physiology; Animals; Cell Differentiation--physiology; Exercise--physiology; Hindlimb Suspension; Humans; Insulin-Like Growth Factor I--physiology; Muscle, Skeletal--physiology; Muscular Dystrophy, Duchenne--physiopathology; Regeneration--physiology; Research; Satellite Cells, Skeletal Muscle--cytology; Satellite Cells, Skeletal Muscle--physiology
PubMed ID: 19169178
Date Deposited: 09 Apr 2014 16:40
Last Modified: 04 Aug 2019 03:55
URI: http://d-scholarship.pitt.edu/id/eprint/21051

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