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Perivascular multi-lineage progenitor cells in human organs: Regenerative units, cytokine sources or both?

Chen, CW and Montelatici, E and Crisan, M and Corselli, M and Huard, J and Lazzari, L and Péault, B (2009) Perivascular multi-lineage progenitor cells in human organs: Regenerative units, cytokine sources or both? Cytokine and Growth Factor Reviews, 20 (5-6). 429 - 434. ISSN 1359-6101

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Multi-lineage progenitors, e.g. mesenchymal stem cells, persist in adult developed organs, making a windfall for the cell therapist but an enigma for stem cell biologists. Recent results from our own and other laboratories show that the ancestor of these elusive adult stem cells is likely to be found in the perivascular area, explaining the ubiquitous distribution of these cells in the body. We have prospectively identified and purified vascular pericytes in multiple human organs and shown that these cells are potent mesodermal progenitors that give rise to genuine mesenchymal stem cells in culture. Pericytes can differentiate into diverse cell lineages, but also secrete multiple paracrine growth factors/cytokines, which likely explains in part their robust regenerative potential. © 2009 Elsevier Ltd. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Chen, CW
Montelatici, E
Crisan, M
Corselli, M
Huard, J
Lazzari, L
Péault, B
Centers: Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Other Centers, Institutes, Offices, or Units > Stem Cell Research Center
Date: 1 October 2009
Date Type: Publication
Journal or Publication Title: Cytokine and Growth Factor Reviews
Volume: 20
Number: 5-6
Page Range: 429 - 434
DOI or Unique Handle: 10.1016/j.cytogfr.2009.10.014
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
ISSN: 1359-6101
Article Type: Review
MeSH Headings: Adult; Animal Structures--cytology; Animal Structures--physiology; Animals; Blood Vessels--cytology; Cell Lineage--physiology; Cytokines--metabolism; Heart Failure--prevention & control; Humans; Models, Biological; Multipotent Stem Cells--metabolism; Multipotent Stem Cells--physiology; Muscle Development--physiology; Pericytes--cytology; Pericytes--metabolism; Pericytes--physiology; Pericytes--transplantation; Regeneration--physiology
PubMed ID: 19926515
Date Deposited: 09 Apr 2014 15:37
Last Modified: 29 Jan 2019 15:56


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