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Regenerative medicine for the musculoskeletal system based on muscle-derived stem cells

Gates, Charley B and Karthikeyan, Tharun and Fu, Freddie H and Huard, Johnny (2008) Regenerative medicine for the musculoskeletal system based on muscle-derived stem cells. The Journal of the American Academy of Orthopaedic Surgeons, 16 (2). 68 - 76. ISSN 1067-151X

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The identification and characterization of stem cells is introducing a paradigm shift in the field of orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue. Muscle-derived stem cells have an application in regeneration of articular cartilage, bone, and skeletal muscle. These postnatal (ie, adult) stem cells can be readily isolated via muscle biopsy. They can display long-term proliferation, high self-renewal, and multipotent differentiation. They also can be genetically modified to secrete growth factors important to tissue healing, thereby functioning as implantable, long-lasting reservoirs for these molecules. Taken together, this evidence suggests that muscle-derived stem cells are well suited for gene therapy and tissue engineering applications for the musculoskeletal system. Effective implementation of even just a few applications of muscle-derived stem cell-based tissue engineering has the potential to revolutionize the way certain musculoskeletal diseases are managed.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Gates, Charley B
Karthikeyan, Tharun
Fu, Freddie Hffu@pitt.eduFFU
Huard, Johnny
Centers: Other Centers, Institutes, Offices, or Units > Stem Cell Research Center
Date: February 2008
Date Type: Publication
Journal or Publication Title: The Journal of the American Academy of Orthopaedic Surgeons
Volume: 16
Number: 2
Publisher: American Academy of Orthopaedic Surgeons
Page Range: 68 - 76
Schools and Programs: School of Medicine > Biochemistry and Molecular Genetics
School of Medicine > Orthopaedic Surgery
Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 1067-151X
Related URLs:
Article Type: Research Article
MeSH Headings: Animals; Cell Differentiation--physiology; Humans; Musculoskeletal Diseases--therapy; Musculoskeletal Physiological Phenomena; Regenerative Medicine--methods; Satellite Cells, Skeletal Muscle--physiology; Satellite Cells, Skeletal Muscle--transplantation; Stem Cells--physiology; Wound Healing--physiology
PubMed ID: 18252837
Date Deposited: 09 Apr 2014 15:37
Last Modified: 01 Nov 2017 13:57


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