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The Role of human herpesvirus and GBV-C coinfections in the development of non-Hodgkin's lymphoma in HIV-1 positive individuals in the multicenter AIDS cohort study

Suder, Natalie (2014) The Role of human herpesvirus and GBV-C coinfections in the development of non-Hodgkin's lymphoma in HIV-1 positive individuals in the multicenter AIDS cohort study. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Introduction: Infection with the human immunodeficiency virus (HIV) can result in severe immune suppression, often allowing infections that would normally be controlled by the immune system to persist in HIV-positive individuals. Many of these infections can in turn affect the dynamics of HIV disease progression. Specifically, we hypothesize that herpesvirus infections are associated with more rapid progression of HIV-1 disease, and chronic immune activation that can lead to the development of HIV/AIDS-associated cancers. Alternatively, we postulate that GB Virus C coinfection has been shown to have a protective effect against HIV-1 disease progression, and may reduce chronic immune activation in HIV-1 positive individuals.

Methods: This study investigated the associations of cytomegalovirus, Epstein-Barr virus, human herpesvirus 6, human herpesvirus 8, and GB Virus C viral coinfections on the development of non-Hodgkin’s lymphoma in MACS HIV-1 seroconverters pre-combination antiretroviral therapy (cART). 536 seroconverters pre-cART were included in the investigation, including 22 who developed non-Hodgkin’s lymphoma.

Results: HIV-1 seroconverters who developed non-Hodgkin’s lymphoma pre-cART experienced CMV and EBV viremia significantly more frequently than those who did not develop non-Hodgkin’s lymphoma. HIV-1 seroconverters who did not develop non-Hodgkin’s lymphoma pre-cART were more frequently viremic for GBV-C. Levels of EBV viremia were significantly higher in HIV-1 seroconverters who developed non-Hodgkin’s lymphoma, and levels of GBV-C viremia were significantly higher in the HIV-1 seroconverters who did not develop non-Hodgkin’s lymphoma. Additionally, HIV-1 seroconverters who had experienced EBV viremia progressed from HIV-1 seroconversion to lymphoma diagnosis more rapidly than those from whom EBV viremia was never detected. Conversely, those who experienced GBV-C viremia, but never experienced EBV viremia progressed more slowly from HIV-1 seroconversion to non-Hodgkin’s lymphoma.

Discussion: This investigation supports the hypothesis that EBV and CMV coinfections drive HIV-1 disease progression and the development of HIV-associated non-Hodgkin’s lymphoma. The results also suggest that GBV-C plays a protective role against the development of non-Hodgkin’s lymphoma in HIV-1 positive individuals. These findings are of public health significance, because knowledge gained regarding the risks associated with non-Hodgkin’s lymphoma development can contribute to the prevention and early detection of non-Hodgkin’s lymphoma.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Suder, Nataliencs22@pitt.eduNCS22
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorRinaldo, Charles R.rinaldo@pitt.eduRINALDO
Committee MemberChen, Yuecheny@pitt.eduCHENY
Committee MemberBunker, Clareannbunkerc@pitt.eduBUNKERC
Date: 27 June 2014
Date Type: Publication
Defense Date: 15 April 2014
Approval Date: 27 June 2014
Submission Date: 24 April 2014
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 49
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: HIV, MACS, herpesvirus, GBV-C, non-Hodgkin's lymphoma
Date Deposited: 27 Jun 2014 22:36
Last Modified: 15 Nov 2016 14:19
URI: http://d-scholarship.pitt.edu/id/eprint/21444

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