Cao, Shuo
(2014)
Zinc finger, AN1-type domain 2A--a novel target for lung cancer.
Master Essay, University of Pittsburgh.
Abstract
Arsenic is a commonly toxincant found in the natural environment and from anthropogenic sources. Arsenic exposure can produce multiple adverse effects including chronic lung disease and lung cancer. The Ubiquitin Proteasome System (UPS) is involved in disease development and aging, its dysfunction can cause improper degradation of misfolded and unfolded proteins. UPS is regulated, in part, by zinc finger gene, thus zinc finger gene can mediate protein degradation, disease development and aging. Zinc finger AN1-type domain 2A (ZFAND2A) can be induced by arsenic and heat shock, and it plays an important role in maintaining cellular homeostasis and longevity. Here, we present a short review about arsenic-induced diseases, the UPS protein degradation machinery, and ZFAND2A and a preliminary study addressing ZFAND2A expression in NCI-H441 cell (human lung adenocarcinoma epithelial cell line) following treatment with heat shock or sodium arsenite. H441 cells appear to be resistant to the arsenic cytotoxicity and ZFAND2A increased markedly in these cells in response to heat stress or arsenic exposure. Because ZFAND2A is thought to improve UPS function and thus could be viewed as protective to cancer cells, it has significant public health relevance, future studies targeting ZFAND2A may be useful in the development of novel therapies to lung cancer.
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Details
| Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID  |
|---|
| Committee Chair | Leikauf, George | gleikauf@pitt.edu | GLEIKAUF | UNSPECIFIED | | Committee Member | Barchowsky, Aaron | aab20@pitt.edu | AAB20 | UNSPECIFIED | | Committee Member | Kamboh, M. Ilyas | kamboh@pitt.edu | KAMBOH | UNSPECIFIED |
|
| Date: |
March 2014 |
| Date Type: |
Publication |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Publisher: |
University of Pittsburgh |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Environmental and Occupational Health |
| Degree: |
MPH - Master of Public Health |
| Thesis Type: |
Master Essay |
| Refereed: |
Yes |
| Date Deposited: |
11 Aug 2015 21:34 |
| Last Modified: |
02 Jul 2024 11:57 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/21504 |
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