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Zinc finger, AN1-type domain 2A--a novel target for lung cancer

Cao, Shuo (2014) Zinc finger, AN1-type domain 2A--a novel target for lung cancer. Master Essay, University of Pittsburgh.

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Abstract

Arsenic is a commonly toxincant found in the natural environment and from anthropogenic sources. Arsenic exposure can produce multiple adverse effects including chronic lung disease and lung cancer. The Ubiquitin Proteasome System (UPS) is involved in disease development and aging, its dysfunction can cause improper degradation of misfolded and unfolded proteins. UPS is regulated, in part, by zinc finger gene, thus zinc finger gene can mediate protein degradation, disease development and aging. Zinc finger AN1-type domain 2A (ZFAND2A) can be induced by arsenic and heat shock, and it plays an important role in maintaining cellular homeostasis and longevity. Here, we present a short review about arsenic-induced diseases, the UPS protein degradation machinery, and ZFAND2A and a preliminary study addressing ZFAND2A expression in NCI-H441 cell (human lung adenocarcinoma epithelial cell line) following treatment with heat shock or sodium arsenite. H441 cells appear to be resistant to the arsenic cytotoxicity and ZFAND2A increased markedly in these cells in response to heat stress or arsenic exposure. Because ZFAND2A is thought to improve UPS function and thus could be viewed as protective to cancer cells, it has significant public health relevance, future studies targeting ZFAND2A may be useful in the development of novel therapies to lung cancer.


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Cao, Shuoshc87@pitt.eduSHC87
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairLeikauf, Georgegleikauf@pitt.eduGLEIKAUFUNSPECIFIED
Committee MemberBarchowsky, Aaronaab20@pitt.eduAAB20UNSPECIFIED
Committee MemberKamboh, M. Ilyaskamboh@pitt.eduKAMBOHUNSPECIFIED
Date: March 2014
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Environmental and Occupational Health
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 11 Aug 2015 21:34
Last Modified: 17 Sep 2021 12:04
URI: http://d-scholarship.pitt.edu/id/eprint/21504

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