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Injection of skeletal muscle-derived cells into the penis improves erectile function

Kim, Y and De Miguel, F and Usiene, I and Kwon, D and Yoshimura, N and Huard, J and Chancellor, MB (2006) Injection of skeletal muscle-derived cells into the penis improves erectile function. International Journal of Impotence Research, 18 (4). 329 - 334. ISSN 0955-9930

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Abstract

We investigated the effect of intrapenile injection of muscle-derived cells (MDC) on the erectile function in rats with bilateral cavernous nerve injury. Rat MDC were harvested and transduced with a retrovirus expressing the lacZ gene. Hanks' balanced salt solution (HBSS) (20 μl) or MDC (1 × 10 6 cells/side) were injected in each corpora cavernosa immediately before bilateral cavernous nerve transection. Intracavernous pressures (ICP) were measured 2 or 4 weeks after surgery with electrical stimulation of the pelvic nerves. Mean maximal ICP of sham group was significantly lower than that of control group both at 2 and 4 weeks after surgery. When MDC were injected into the penis, ICP improved over the sham-injected group at both 2 and 4 weeks after surgery. Percent area of PGP 9.5 staining was significantly greater in MDC-injected penis than in sham-injected at 2 and 4 weeks. Penile MDC injection can facilitate recovery of injured penile innervation and improve erectile function. © 2006 Nature Publishing Group All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kim, Y
De Miguel, F
Usiene, I
Kwon, D
Yoshimura, N
Huard, J
Chancellor, MB
Date: 17 July 2006
Date Type: Publication
Journal or Publication Title: International Journal of Impotence Research
Volume: 18
Number: 4
Page Range: 329 - 334
DOI or Unique Handle: 10.1038/sj.ijir.3901434
Schools and Programs: School of Medicine > Urology
Refereed: Yes
ISSN: 0955-9930
MeSH Headings: Animals; Cell Transplantation--methods; Erectile Dysfunction--therapy; Female; Injections; Male; Muscle, Skeletal--cytology; Penile Erection--physiology; Penis--cytology; Rats; Rats, Sprague-Dawley
PubMed ID: 16341028
Date Deposited: 09 Jun 2014 14:48
Last Modified: 25 Jan 2019 21:55
URI: http://d-scholarship.pitt.edu/id/eprint/21682

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