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Landmarking the brain for geometric morphometric analysis: An error study

Chollet, MB and Aldridge, K and Pangborn, N and Weinberg, SM and DeLeon, VB (2014) Landmarking the brain for geometric morphometric analysis: An error study. PLoS ONE, 9 (1).

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Neuroanatomic phenotypes are often assessed using volumetric analysis. Although powerful and versatile, this approach is limited in that it is unable to quantify changes in shape, to describe how regions are interrelated, or to determine whether changes in size are global or local. Statistical shape analysis using coordinate data from biologically relevant landmarks is the preferred method for testing these aspects of phenotype. To date, approximately fifty landmarks have been used to study brain shape. Of the studies that have used landmark-based statistical shape analysis of the brain, most have not published protocols for landmark identification or the results of reliability studies on these landmarks. The primary aims of this study were two-fold: (1) to collaboratively develop detailed data collection protocols for a set of brain landmarks, and (2) to complete an intra- and inter-observer validation study of the set of landmarks. Detailed protocols were developed for 29 cortical and subcortical landmarks using a sample of 10 boys aged 12 years old. Average intra-observer error for the final set of landmarks was 1.9 mm with a range of 0.72 mm-5.6 mm. Average inter-observer error was 1.1 mm with a range of 0.40 mm-3.4 mm. This study successfully establishes landmark protocols with a minimal level of error that can be used by other researchers in the assessment of neuroanatomic phenotypes. © 2014 Chollet et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Chollet, MB
Aldridge, K
Pangborn, N
Weinberg, SMsmwst46@pitt.eduSMWST46
DeLeon, VB
ContributionContributors NameEmailPitt UsernameORCID
Date: 28 January 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 1
DOI or Unique Handle: 10.1371/journal.pone.0086005
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
Date Deposited: 19 Jun 2014 16:59
Last Modified: 02 Feb 2019 14:56


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