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The association of cardioprotective medications with pneumonia-related outcomes

Wu, A and Good, C and Downs, JR and Fine, MJ and Pugh, MJV and Anzueto, A and Mortensen, EM (2014) The association of cardioprotective medications with pneumonia-related outcomes. PLoS ONE, 9 (1).

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Introduction: Little research has examined whether cardiovascular medications, other than statins, are associated with improved outcomes after pneumonia. Our aim was to examine the association between the use of beta-blockers, statins, angiotensin converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers (ARBs) with pneumonia-related outcomes. Materials and Methods: We conducted a retrospective population-based study on male patients ≥65 years of age hospitalized with pneumonia and who did not have pre-existing cardiac disease. Our primary analyses were multilevel regression models that examined the association between cardiovascular medication classes and either mortality or cardiovascular events. Results: Our cohort included 21,985 patients: 22% died within 90 days of admission, and 22% had a cardiac event within 90 days. The cardiovascular medications studied that were associated with decreased 90-day mortality included: statins (OR 0.70, 95% CI 0.63-0.77), ACE inhibitors (OR 0.82, 95% CI 0.74-0.91), and ARBs (OR 0.58, 95% CI 0.44-0.77). However, none of the medications were significantly associated with decreased cardiovascular events. Discussion: While statins, ACE inhibitors, and ARBs, were associated with decreased mortality, there was no significant association with decreased CV events. These results indicate that this decreased mortality is unlikely due to their potential cardioprotective effects.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Wu, A
Good, Ccbg15@pitt.eduCBG15
Downs, JR
Fine, MJmjf1@pitt.eduMJF10000-0003-3470-9846
Pugh, MJV
Anzueto, A
Mortensen, EM
ContributionContributors NameEmailPitt UsernameORCID
Date: 28 January 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 1
DOI or Unique Handle: 10.1371/journal.pone.0085797
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Date Deposited: 17 Jun 2014 14:57
Last Modified: 01 Nov 2021 10:55


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