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Total and high-molecular-weight adiponectin levels in relation to insulin resistance among overweight/obese adults.

Acharya, Sushama D and Evans, Rhobert W and Brooks, Maria M and Linkov, Faina and Burke, Lora E (2013) Total and high-molecular-weight adiponectin levels in relation to insulin resistance among overweight/obese adults. Cent Asian J Glob Health, 2 (2). 55 - ?.

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Abstract

Objective: To determine whether baseline levels or intervention-associated changes in total and high molecular weight (HMW) adiponectin levels were associated with insulin resistance after six months of behavioral treatment for weight loss. Design: An ancillary study to a behavioral weight loss trial; the intervention was delivered in group sessions. Methods: Participants included 143 overweight/obese adults with a mean BMI of 33.7 kg/m2. The sample was 88% female, 67% white, and 44.2 ± 8.5 years old. Circulating adiponectin levels (total and HMW) and the homeostasis model assessment (HOMA) of insulin resistance were measured and evaluated. Results: At baseline, there was significant inverse associations between total adiponectin and HOMA (p < 0.001) and between HMW adiponectin and HOMA (p < 0.001) independent of weight. At 6-mo, there was a 17% improvement in HOMA, 8% increase in total adiponectin, 17% increase in HMW adiponectin levels, and 8.72% weight loss (p's for all< 0.001). There was also a significant inverse association between changes in total adiponectin and HOMA (p = 0.04) that was independent of baseline weight and weight loss. In contrast, the association between changes in HMW adiponectin and HOMA was attenuated after adjustment for weight loss. Conclusions: An increased level of total adiponectin was associated with improved insulin sensitivity, regardless of baseline weight and weight loss. However, baseline total and HMW adiponectin levels were more strongly associated with HOMA than changes in these measures at six months. HMW adiponectin level was not related more closely to insulin resistance than total adiponectin level.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Acharya, Sushama D
Evans, Rhobert WEvansR@edc.pitt.eduRWE2
Brooks, Maria MMBROOKS@pitt.eduMBROOKS
Linkov, Fainafyl1@pitt.eduFYL1
Burke, Lora Elbu100@pitt.eduLBU100
Date: 2013
Date Type: Publication
Journal or Publication Title: Cent Asian J Glob Health
Volume: 2
Number: 2
Page Range: 55 - ?
DOI or Unique Handle: 10.5195/cajgh.2013.55
Schools and Programs: Graduate School of Public Health > Epidemiology
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
School of Nursing > Nursing
Refereed: Yes
Uncontrolled Keywords: Adiponectin, high molecular weight adiponectin, homeostasis model assessment of insulin resistance (HOMA), insulin resistance, weight loss and adiponectin levels
Funders: NIDDK NIH HHS (R01 DK058631), NINR NIH HHS (K24 NR010742), NIDDK NIH HHS (P30 DK046204), NCRR NIH HHS (M01 RR000056), NINR NIH HHS (P30 NR003924)
Date Deposited: 30 Jun 2014 16:06
Last Modified: 22 May 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/21957

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