Paula, AA and Schechter, M and Tuboi, SH and Faulhaber, JC and Luz, PM and Veloso, VG and Moreira, RI and Grinsztejn, B and Harrison, LH and Pacheco, AG
(2014)
Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: An analysis of nationwide data.
PLoS ONE, 9 (4).
Abstract
Introduction: After antiretroviral therapy (ART) became available, there was a decline in the number of deaths in persons infected with HIV. Thereafter, there was a decrease in the proportion of deaths attributed to opportunistic infections and an increase in the proportion of deaths attributed to chronic comorbidities. Herein we extend previous observations from a nationwide survey on temporal trends in causes of death in HIV-infected patients in Brazil. Methods: We describe temporal trends in causes of death among adults who had HIV/AIDS listed in the death certificate to those who did not. All death certificates issued in Brazil from 1999 to 2011 and listed in the national mortality database were included. Generalized linear mixed-effects logistic models were used to study temporal trends in proportions. Results: In the HIV-infected population, there was an annual adjusted average increase of 6.0%, 12.0%, 4.0% and 4.1% for cancer, external causes, cardiovascular diseases (CVD) and diabetes mellitus (DM), respectively, compared to 3.0%, 4.0%, 1.0% and 3.9%, in the non-HIV group. For tuberculosis (TB), there was an adjusted average increase of 0.3%/year and a decrease of 3.0%/year in the HIV and the non-HIV groups, respectively. Compared to 1999, the odds ratio (OR) for cancer, external causes, CVD, DM, or TB in the HIV group were, respectively, 2.31, 4.17, 1.76, 2.27 and 1.02, while for the non-HIV group, the corresponding OR were 1.31, 1.63, 1.14, 1.62 and 0.67. Interactions between year as a continuous or categorical variable and HIV were significant (p <0.001) for all conditions, except for DM when year was considered as a continuous variable (p = 0.76). Conclusions: Non HIV-related co-morbidities continue to increase more rapidly as causes of death among HIV-infected individuals than in those without HIV infection, highlighting the need for targeting prevention measures and surveillance for chronic diseases among those patients. © 2014 Paula et al.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Paula, AA | | | | | Schechter, M | | | | | Tuboi, SH | | | | | Faulhaber, JC | | | | | Luz, PM | | | | | Veloso, VG | | | | | Moreira, RI | | | | | Grinsztejn, B | | | | | Harrison, LH | lharriso@edc.pitt.edu | LHARRISO | | | Pacheco, AG | | | |
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| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID |
|---|
| Editor | Okulicz, Jason F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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| Date: |
11 April 2014 |
| Date Type: |
Publication |
| Journal or Publication Title: |
PLoS ONE |
| Volume: |
9 |
| Number: |
4 |
| DOI or Unique Handle: |
10.1371/journal.pone.0094636 |
| Schools and Programs: |
School of Public Health > Epidemiology
School of Public Health > Infectious Diseases and Microbiology |
| Refereed: |
Yes |
| Date Deposited: |
23 Jun 2014 21:06 |
| Last Modified: |
04 Feb 2019 15:56 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/21978 |
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