Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Circulating mediators of inflammation and immune activation in AIDS-related non-Hodgkin lymphoma

Nolen, BM and Breen, EC and Bream, JH and Jenkins, FJ and Kingsley, LA and Rinaldo, CR and Lokshin, AE (2014) Circulating mediators of inflammation and immune activation in AIDS-related non-Hodgkin lymphoma. PLoS ONE, 9 (6).

Published Version
Available under License : See the attached license file.

Download (638kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-related malignancy in developed countries. An elevated risk of developing NHL persists among HIV-infected individuals in comparison to the general population despite the advent of effective antiretroviral therapy. The mechanisms underlying the development of AIDS-related NHL (A-NHL) are not fully understood, but likely involve persistent B-cell activation and inflammation. Methods: This was a nested case-control study within the ongoing prospective Multicenter AIDS Cohort Study (MACS). Cases included 47 HIV-positive male subjects diagnosed with high-grade B-cell NHL. Controls were matched to each case from among participating HIV-positive males who did not develop any malignancy. Matching criteria included time HIV+ or since AIDS diagnosis, age, race and CD4+ cell count. Sera were tested for 161 serum biomarkers using multiplexed beadbased immunoassays. Results: A subset of 17 biomarkers, including cytokines, chemokines, acute phase proteins, tissue remodeling agents and bone metabolic mediators was identified to be significantly altered in A-NHL cases in comparison to controls. Many of the biomarkers included in this subset were positively correlated with HIV viral load. A pathway analysis of our results revealed an extensive network of interactions between current and previously identified biomarkers. Conclusions: These findings support the current hypothesis that A-NHL develops in the context of persistent immune stimulation and inflammation. Further analysis of the biomarkers identified in this report should enhance our ability to diagnose, monitor and treat this disease. © 2014 Nolen et al.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Nolen, BMbmn9@pitt.eduBMN9
Breen, EC
Bream, JH
Jenkins, FJfjenkins@pitt.eduFJENKINS
Kingsley, LAkingsley@pitt.eduKINGSLEY
Rinaldo, CRRINALDO@pitt.eduRINALDO
Lokshin, AElokshina@pitt.eduLOKSHINA
ContributionContributors NameEmailPitt UsernameORCID
Date: 12 June 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 6
DOI or Unique Handle: 10.1371/journal.pone.0099144
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
School of Medicine > Medicine
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
School of Medicine > Pathology
Refereed: Yes
Date Deposited: 30 Jun 2014 18:38
Last Modified: 02 Feb 2019 15:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item