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Circulating mediators of inflammation and immune activation in AIDS-related non-Hodgkin lymphoma

Nolen, BM and Breen, EC and Bream, JH and Jenkins, FJ and Kingsley, LA and Rinaldo, CR and Lokshin, AE (2014) Circulating mediators of inflammation and immune activation in AIDS-related non-Hodgkin lymphoma. PLoS ONE, 9 (6).

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Abstract

Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-related malignancy in developed countries. An elevated risk of developing NHL persists among HIV-infected individuals in comparison to the general population despite the advent of effective antiretroviral therapy. The mechanisms underlying the development of AIDS-related NHL (A-NHL) are not fully understood, but likely involve persistent B-cell activation and inflammation. Methods: This was a nested case-control study within the ongoing prospective Multicenter AIDS Cohort Study (MACS). Cases included 47 HIV-positive male subjects diagnosed with high-grade B-cell NHL. Controls were matched to each case from among participating HIV-positive males who did not develop any malignancy. Matching criteria included time HIV+ or since AIDS diagnosis, age, race and CD4+ cell count. Sera were tested for 161 serum biomarkers using multiplexed beadbased immunoassays. Results: A subset of 17 biomarkers, including cytokines, chemokines, acute phase proteins, tissue remodeling agents and bone metabolic mediators was identified to be significantly altered in A-NHL cases in comparison to controls. Many of the biomarkers included in this subset were positively correlated with HIV viral load. A pathway analysis of our results revealed an extensive network of interactions between current and previously identified biomarkers. Conclusions: These findings support the current hypothesis that A-NHL develops in the context of persistent immune stimulation and inflammation. Further analysis of the biomarkers identified in this report should enhance our ability to diagnose, monitor and treat this disease. © 2014 Nolen et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nolen, BMbmn9@pitt.eduBMN9
Breen, EC
Bream, JH
Jenkins, FJfjenkins@pitt.eduFJENKINS
Kingsley, LAkingsley@pitt.eduKINGSLEY
Rinaldo, CRRINALDO@pitt.eduRINALDO
Lokshin, AElokshina@pitt.eduLOKSHINA
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorUnutmaz, DeryaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 12 June 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 6
DOI or Unique Handle: 10.1371/journal.pone.0099144
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
School of Medicine > Medicine
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
School of Medicine > Pathology
Refereed: Yes
Date Deposited: 30 Jun 2014 18:38
Last Modified: 02 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/22107

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