A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process

Werner, S and Turner, DM and Lyon, MA and Huryn, DM and Wipf, P (2006) A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process. Synlett (14). 2334 - 2338. ISSN 0936-5214

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Abstract

A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relationship studies of biological lead molecules. The tandem Biginelli-Ugi multi-component reaction facilitated the effective variation of four different substituents and allowed the synthesis of the library members in a sequence of only two one-pot reactions. © Georg Thieme Verlag Stuttgart.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Werner, S Turner, DM Lyon, MA Huryn, DM Wipf, P pwipf@pitt.edu PWIPF
Date:	1 September 2006
Date Type:	Publication
Journal or Publication Title:	Synlett
Number:	14
Page Range:	2334 - 2338
DOI or Unique Handle:	10.1055/s-2006-949648
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0936-5214
Date Deposited:	18 Jul 2014 21:08
Last Modified:	02 Feb 2019 16:57
URI:	http://d-scholarship.pitt.edu/id/eprint/22172

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