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Mitochondrial targeting of radioprotectants using peptidyl conjugates

Kanai, A and Zabbarova, I and Amoscato, A and Epperly, M and Xiao, J and Wipf, P (2007) Mitochondrial targeting of radioprotectants using peptidyl conjugates. Organic and Biomolecular Chemistry, 5 (2). 307 - 309. ISSN 1477-0520

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Ionizing radiation activates a mitochondrial nitric oxide synthase, leading to inhibition of the respiratory chain, generation of excess superoxide, peroxynitrite production and nitrosative damage. We have measured the radioprotective effects of a nitric oxide synthase antagonist (AMT) versus a free radical scavenger (4-amino-TEMPO) using electrochemical detection of nitric oxide and peroxynitrite. To enhance their efficacy, we have conjugated these compounds to peptides and peptide isosteres - derived from the antibiotic gramicidin S - that target the mitochondria. The targeting ability of these peptidyl conjugates was measured using quantitative mass spectrometry. © The Royal Society of Chemistry.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kanai, A
Zabbarova, I
Amoscato, Aaaa5@pitt.eduAAA5
Epperly, M
Xiao, J
Wipf, Ppwipf@pitt.eduPWIPF
Date: 1 January 2007
Date Type: Publication
Journal or Publication Title: Organic and Biomolecular Chemistry
Volume: 5
Number: 2
Page Range: 307 - 309
DOI or Unique Handle: 10.1039/b613334g
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1477-0520
MeSH Headings: Animals; Cyclic N-Oxides--chemistry; Electrochemistry; Gramicidin--chemistry; Mass Spectrometry; Mitochondria--metabolism; Models, Chemical; Nitric Oxide--chemistry; Nitric Oxide Synthase--antagonists & inhibitors; Peptides--chemistry; Peroxynitrous Acid--chemistry; Submitochondrial Particles--chemistry; Superoxides
Other ID: NLM NIHMS264267, NLM PMC3032592
PubMed Central ID: PMC3032592
PubMed ID: 17205174
Date Deposited: 07 Jul 2014 16:22
Last Modified: 02 Feb 2019 15:55


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