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Protein kinase D as a potential new target for cancer therapy

LaValle, CR and George, KM and Sharlow, ER and Lazo, JS and Wipf, P and Wang, QJ (2010) Protein kinase D as a potential new target for cancer therapy. Biochimica et Biophysica Acta - Reviews on Cancer, 1806 (2). 183 - 192. ISSN 0304-419X

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Protein kinase D is a novel family of serine/threonine kinases and diacylglycerol receptors that belongs to the calcium/calmodulin-dependent kinase superfamily. Evidence has established that specific PKD isoforms are dysregulated in several cancer types, and PKD involvement has been documented in a variety of cellular processes important to cancer development, including cell growth, apoptosis, motility, and angiogenesis. In light of this, there has been a recent surge in the development of novel chemical inhibitors of PKD. This review focuses on the potential of PKD as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of PKD inhibitors. © 2010 Elsevier B.V.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
LaValle, CR
George, KM
Sharlow, ER
Lazo, JS
Wipf, Ppwipf@pitt.eduPWIPF
Wang, QJ
Date: 1 December 2010
Date Type: Publication
Journal or Publication Title: Biochimica et Biophysica Acta - Reviews on Cancer
Volume: 1806
Number: 2
Page Range: 183 - 192
DOI or Unique Handle: 10.1016/j.bbcan.2010.05.003
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0304-419X
Article Type: Review
MeSH Headings: Cell Movement; Humans; Neoplasm Invasiveness; Neoplasms--drug therapy; Neoplasms--enzymology; Neoplasms--pathology; Protein Kinase C--analysis; Protein Kinase C--antagonists & inhibitors; Protein Kinase Inhibitors--therapeutic use; Signal Transduction
Other ID: NLM NIHMS208514, NLM PMC2947595
PubMed Central ID: PMC2947595
PubMed ID: 20580776
Date Deposited: 18 Jul 2014 21:18
Last Modified: 02 Feb 2019 15:57


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