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Sex Determination: Why So Many Ways of Doing It?

Bachtrog, D and Mank, JE and Peichel, CL and Kirkpatrick, M and Otto, SP and Ashman, TL and Hahn, MW and Kitano, J and Mayrose, I and Ming, R and Perrin, N and Ross, L and Valenzuela, N and Vamosi, JC and Blackmon, H and Goldberg, EE and Hahn, MW and Kirkpatrick, M and Kitano, J and Ming, R and Pennell, MW (2014) Sex Determination: Why So Many Ways of Doing It? PLoS Biology, 12 (7). 1 - 13. ISSN 1544-9173

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Sexual reproduction is an ancient feature of life on earth, and the familiar X and Y chromosomes in humans and other model species have led to the impression that sex determination mechanisms are old and conserved. In fact, males and females are determined by diverse mechanisms that evolve rapidly in many taxa. Yet this diversity in primary sex-determining signals is coupled with conserved molecular pathways that trigger male or female development. Conflicting selection on different parts of the genome and on the two sexes may drive many of these transitions, but few systems with rapid turnover of sex determination mechanisms have been rigorously studied. Here we survey our current understanding of how and why sex determination evolves in animals and plants and identify important gaps in our knowledge that present exciting research opportunities to characterize the evolutionary forces and molecular pathways underlying the evolution of sex determination. © 2014 Bachtrog et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Bachtrog, D
Mank, JE
Peichel, CL
Kirkpatrick, M
Otto, SP
Ashman, TLtia1@pitt.eduTIA10000-0002-9884-5954
Hahn, MW
Kitano, J
Mayrose, I
Ming, R
Perrin, N
Ross, L
Valenzuela, N
Vamosi, JC
Blackmon, H
Goldberg, EE
Hahn, MW
Kirkpatrick, M
Kitano, J
Ming, R
Pennell, MW
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: PLoS Biology
Volume: 12
Number: 7
Page Range: 1 - 13
DOI or Unique Handle: 10.1371/journal.pbio.1001899
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 1544-9173
Date Deposited: 23 Sep 2014 16:16
Last Modified: 26 Oct 2021 12:55


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