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Controlled Delivery of Bioactive Factors for Tissue Regeneration

Johnson, Noah Ray (2015) Controlled Delivery of Bioactive Factors for Tissue Regeneration. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Growth factors have enormous clinical potential as they orchestrate all repair and regenerative processes in the body. However, their half-lives in vivo when applied alone are very short, on the order of minutes to hours. Therefore, large doses and multiple applications are necessary which is expensive and raises safety concerns considering their potency. To address this issue we developed a coacervate delivery system which protects growth factors from degradation and sustains and localizes their release at the site of injection. By imitating the native signaling environment involving ligands, proteoglycans, and cell receptors our delivery vehicle also enhances growth factor bioactivity, enabling the use of minute and clinically-safe dosages. This dissertation describes the translational potential of this growth factor therapy to address three significant clinical needs: 1) Diabetic wound healing, 2) Cardiac repair following myocardial infarction, 3) Bone regeneration for congenital defects and trauma.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Johnson, Noah Raynoj2@pitt.eduNOJ2
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWang, Yadongyaw20@pitt.eduYAW20
Committee MemberFederspiel,
Committee MemberHebda, Patricia A.hebda@pitt.eduHEBDA
Committee MemberWells, Alanwellsa@msx.upmc.eduAHW6
Date: 9 April 2015
Date Type: Publication
Defense Date: 25 November 2014
Approval Date: 9 April 2015
Submission Date: 12 November 2014
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 191
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords:
Date Deposited: 09 Apr 2016 05:00
Last Modified: 19 Dec 2016 14:42


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