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Investigation of Interslice Magnetization Transfer Effects as a New Method for MTR Imaging of the Human Brain

Barker, Jeffrey and Han, Paul Kyu and Choi, Seung Hong and Bae, Kyongtae Ty and Park, Sung-Hong (2014) Investigation of Interslice Magnetization Transfer Effects as a New Method for MTR Imaging of the Human Brain. PLOS ONE. (Submitted)

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We present a new method for magnetization transfer (MT) ratio imaging in the brain that requires no separate saturation pulse. Interslice MT effects that are inherent to multi-slice balanced steady-state free precession (bSSFP) imaging were controlled via an interslice delay time to generate MT-weighted (0 s delay) and reference images (5-8 s delay) for MT ratio (MTR) imaging of the brain. The effects of varying flip angle and phase encoding (PE) order were investigated experimentally in normal, healthy subjects. Values of up to ~50% and ~40% were observed for white and gray matter MTR. Centric PE showed larger MTR, higher SNR, and better contrast between white and gray matter than linear PE. Simulations of a two-pool model of MT agreed well with in vivo MTR values. Simulations were also used to investigate the effects of varying acquisition parameters, and the effects of varying flip angle, PE steps, and interslice delay are discussed. Lastly, we demonstrated reduced banding with a non-balanced SSFP-FID sequence and showed preliminary results of interslice MTR imaging of meningioma.


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Item Type: Article
Status: Submitted
CreatorsEmailPitt UsernameORCID
Barker, Jeffreyjwb52@pitt.eduJWB52
Han, Paul
Choi, Seung
Bae, Kyongtae
Date: 3 December 2014
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLOS ONE
Institution: University of Pittsburgh
Refereed: No
Article Type: Research Article
Date Deposited: 18 Dec 2014 15:53
Last Modified: 15 Nov 2016 14:25


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