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PEPTIDE-BASED METHODS FOR ASSEMBLING AND CONTROLLING THE MORPHOLOGIES, METRICS, AND PROPERTIES OF GOLD NANOPARTICLE SUPERSTRUCTURES

Zhang, Chen (2015) PEPTIDE-BASED METHODS FOR ASSEMBLING AND CONTROLLING THE MORPHOLOGIES, METRICS, AND PROPERTIES OF GOLD NANOPARTICLE SUPERSTRUCTURES. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

This dissertation describes new peptide-based methods for assembling and controlling the morphologies, metrics, and properties of gold nanoparticle superstructures. The aim of this research is to develop the peptide-based method by modifying the peptide sequences and controlling the reaction conditions for the synthesis and assembly of gold nanoparticle superstructures to achieve reliable control over their morphology and metrics, and furthermore study their properties and applications.
With this goal in mind, the C-terminus of a gold-binding peptide was modified with different numbers of hydrophobic phenylalanines to affect peptide assembly and ultimately nanoparticle assembly. The addition of hydrophobic phenylalanines to the C-terminus of peptide conjugates promoted fiber bundling which in turn lead to the formation of thick or intertwined 1-D nanoparticle superstructures. Furthermore, I prepared spherical gold nanoparticle superstructures with varied diameters (~40nm, ~75nm, and ~150nm) and visible to near-infrared optical properties by using a single peptide conjugate molecule yet varied reaction conditions. Theoretical simulation and experiment were coupled to further understand their optical properties. Finally, I studied and demonstrated the drug storage and release properties of hollow spherical gold nanoparticle superstructures; this was the first demonstrated application of this class of nanoparticle superstructure.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zhang, Chenzhangchen1987115@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairRosi, Nathaniel Lnrosi@pitt.eduNROSI
Committee MemberWeber, Stephen Gsweber@pitt.eduSWEBER
Committee MemberStar, Alexanderastar@pitt.eduASTAR
Committee MemberArmitage, Brucearmy@andrew.cmu.edu
Date: 23 June 2015
Date Type: Publication
Defense Date: 16 February 2015
Approval Date: 23 June 2015
Submission Date: 16 March 2015
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 129
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: peptide, gold, self-assembly, nanoparticle, superstructure
Date Deposited: 23 Jun 2015 18:11
Last Modified: 15 Nov 2016 14:26
URI: http://d-scholarship.pitt.edu/id/eprint/24062

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