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Impact of emphysema heterogeneity on pulmonary function

Ju, J and Li, R and Gu, S and Leader, JK and Wang, X and Chen, Y and Zheng, B and Wu, S and Gur, D and Sciurba, F and Pu, J (2014) Impact of emphysema heterogeneity on pulmonary function. PLoS ONE, 9 (11).

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Results: The majority (128/160) of the subjects with COPD had a heterogeneity greater than zero. After adjusting for age, gender, smoking history, and extent of emphysema, heterogeneity in depicted disease in upper lobe dominant cases was positively associated with pulmonary function measures, such as FEV1 Predicted (p<.001) and FEV1/FVC (p<.001), as well as disease severity (p<0.05). We found a negative association between HI% , RV/TLC (p<0.001), and DLco% (albeit not a statistically significant one, p = 0.06) in this group of patients.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ju, J
Li, Rrul12@pitt.eduRUL12
Gu, S
Leader, JKjklst3@pitt.eduJKLST3
Wang, X
Chen, Y
Zheng, B
Wu, S
Gur, Dgur@pitt.eduGUR
Sciurba, Ffcs@pitt.eduFCS
Pu, Jjip13@pitt.eduJIP13
ContributionContributors NameEmailPitt UsernameORCID
Date: 19 November 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 11
DOI or Unique Handle: 10.1371/journal.pone.0113320
Schools and Programs: School of Public Health > Biostatistics
School of Medicine > Medicine
School of Medicine > Radiology
Swanson School of Engineering > Bioengineering
Refereed: Yes
Other ID: NLM PMC4237430
PubMed Central ID: PMC4237430
PubMed ID: 25409328
Date Deposited: 12 May 2015 18:31
Last Modified: 30 Mar 2021 16:55


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