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Processing of spatial-frequency altered faces in schizophrenia: Effects of illness phase and duration

Silverstein, SM and Keane, BP and Feigenson, K and Roché, MW and Wang, Y and Mikkilineni, D and Paterno, D and Papathomas, TV and Kourtev, H and Lathrop, KL (2014) Processing of spatial-frequency altered faces in schizophrenia: Effects of illness phase and duration. PLoS ONE, 9 (12).

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Abstract

© 2014 Silverstein et al. Low spatial frequency (SF) processing has been shown to be impaired in people with schizophrenia, but it is not clear how this varies with clinical state or illness chronicity. We compared schizophrenia patients (SCZ, n534), first episode psychosis patients (FEP, n522), and healthy controls (CON, n535) on a gender/facial discrimination task. Images were either unaltered (broadband spatial frequency, BSF), or had high or low SF information removed (LSF and HSF conditions, respectively). The task was performed at hospital admission and discharge for patients, and at corresponding time points for controls. Groups were matched on visual acuity. At admission, compared to their BSF performance, each group was significantly worse with low SF stimuli, and most impaired with high SF stimuli. The level of impairment at each SF did not depend on group. At discharge, the SCZ group performed more poorly in the LSF condition than the other groups, and showed the greatest degree of performance decline collapsed over HSF and LSF conditions, although the latter finding was not significant when controlling for visual acuity. Performance did not change significantly over time for any group. HSF processing was strongly related to visual acuity at both time points for all groups. We conclude the following: 1) SF processing abilities in schizophrenia are relatively stable across clinical state; 2) face processing abnormalities in SCZ are not secondary to problems processing specific SFs, but are due to other known difficulties constructing visual representations from degraded information; and 3) the relationship between HSF processing and visual acuity, along with known SCZ- and medication-related acuity reductions, and the elimination of a SCZ-related impairment after controlling for visual acuity in this study, all raise the possibility that some prior findings of impaired perception in SCZ may be secondary to acuity reductions.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Silverstein, SM
Keane, BP
Feigenson, K
Roché, MW
Wang, Y
Mikkilineni, D
Paterno, D
Papathomas, TV
Kourtev, H
Lathrop, KLkll21@pitt.eduKLL21
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorStarrfelt, RandiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 8 December 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 12
DOI or Unique Handle: 10.1371/journal.pone.0114642
Schools and Programs: School of Medicine > Ophthalmology
Swanson School of Engineering > Bioengineering
Refereed: Yes
Other ID: NLM PMC4259337
PubMed Central ID: PMC4259337
PubMed ID: 25485784
Date Deposited: 12 May 2015 18:43
Last Modified: 25 Jan 2019 20:55
URI: http://d-scholarship.pitt.edu/id/eprint/24073

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