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Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study: The Korean Sarcopenic Obesity Study (KSOS)

Kim, TN and Park, MS and Ryu, JY and Choi, HY and Hong, HC and Yoo, HJ and Kang, HJ and Song, W and Park, SW and Baik, SH and Newman, AB and Choi, KM (2014) Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study: The Korean Sarcopenic Obesity Study (KSOS). PLoS ONE, 9 (12).

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Abstract

Objectives: Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. Methods: We observed changes in anthropometric and body composition data during a follow-up period of 27.6±2.8 months in 379 Korean men and women (mean age 51.9±14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. Results: ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). Conclusions: This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kim, TN
Park, MS
Ryu, JY
Choi, HY
Hong, HC
Yoo, HJ
Kang, HJ
Song, W
Park, SW
Baik, SH
Newman, ABANEWMAN@pitt.eduANEWMAN
Choi, KM
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorAnderson, Rozalyn M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 17 December 2014
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 9
Number: 12
DOI or Unique Handle: 10.1371/journal.pone.0115407
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
Other ID: NLM PMC4269440
PubMed Central ID: PMC4269440
PubMed ID: 25517117
Date Deposited: 12 May 2015 18:44
Last Modified: 27 Mar 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/24076

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