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Repression of CC16 by cigarette smoke (CS) exposure

Zhu, L and Di, PYP and Wu, R and Pinkerton, KE and Chen, Y (2015) Repression of CC16 by cigarette smoke (CS) exposure. PLoS ONE, 10 (1).

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Abstract

© 2015 Zhu et al. Club (Clara) Cell Secretory Protein (CCSP, or CC16) is produced mainly by non-ciliated airway epithelial cells including bronchiolar club cells and the change of its expression has been shown to associate with the progress and severity of Chronic Obstructive Pulmonary Disease (COPD). In an animal model, the lack of CC16 renders the animal susceptible to the tumorigenic effect of a major CS carcinogen. A recent population-based Tucson Epidemiological Study of Airway Obstructive Diseases (TESAOD) has indicated that the low serum CC16 concentration is closely linked with the smoke-related mortality, particularly that driven by the lung cancer. However, the study of CC16 expression in well-defined smoke exposure models has been lacking, and there is no experimental support for the potential causal link between CC16 and CS-induced pathophysiological changes in the lung. In the present study, we have found that airway CC16 expression was significantly repressed in COPD patients, in monkey CS exposure model, and in CS-induced mouse model of COPD. Additionally, the lack of CC16 exacerbated airway inflammation and alveolar loss in the mouse model. Therefore, CC16 may play an important protective role in CS-related diseases.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zhu, L
Di, PYP
Wu, R
Pinkerton, KE
Chen, Y
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorChu, Hong WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 30 January 2015
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 1
DOI or Unique Handle: 10.1371/journal.pone.0116159
Schools and Programs: Graduate School of Public Health > Environmental and Occupational Health
Refereed: Yes
Other ID: NLM PMC4312097
PubMed Central ID: PMC4312097
PubMed ID: 25635997
Date Deposited: 12 May 2015 19:52
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/24084

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