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Investigation of inter-slice magnetization transfer effects as a new method for MTR imaging of the human brain

Barker, JW and Han, PK and Choi, SH and Bae, KT and Park, SH (2015) Investigation of inter-slice magnetization transfer effects as a new method for MTR imaging of the human brain. PLoS ONE, 10 (2).

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Abstract

Copyright © 2015 Barker et al. We present a new method for magnetization transfer (MT) ratio imaging in the brain that requires no separate saturation pulse. Interslice MT effects that are inherent to multi-slice balanced steady-state free precession (bSSFP) imaging were controlled via an interslice delay time to generate MT-weighted (0 s delay) and reference images (5-8 s delay) for MT ratio (MTR) imaging of the brain. The effects of varying flip angle and phase encoding (PE) order were investigated experimentally in normal, healthy subjects. Values of up to ∼ 50% and ∼ 40% were observed for white and gray matter MTR. Centric PE showed larger MTR, higher SNR, and better contrast between white and gray matter than linear PE. Simulations of a two-pool model of MT agreed well with in vivo MTR values. Simulations were also used to investigate the effects of varying acquisition parameters, and the effects of varying flip angle, PE steps, and interslice delay are discussed. Lastly, we demonstrated reduced banding with a non-balanced SSFP-FID sequence and showed preliminary results of interslice MTR imaging of meningioma.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Barker, JW
Han, PK
Choi, SH
Bae, KT
Park, SH
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorLui, SuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 10 February 2015
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 2
DOI or Unique Handle: 10.1371/journal.pone.0117101
Schools and Programs: School of Medicine > Radiology
Swanson School of Engineering > Bioengineering
Refereed: Yes
Other ID: NLM PMC4321840
PubMed Central ID: PMC4321840
PubMed ID: 25664938
Date Deposited: 12 May 2015 18:19
Last Modified: 02 Feb 2019 16:58
URI: http://d-scholarship.pitt.edu/id/eprint/24092

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