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Gait speed and survival in older adults

Studenski, S and Perera, S and Patel, K and Rosano, C and Faulkner, K and Inzitari, M and Brach, J and Chandler, J and Cawthon, P and Connor, EB and Nevitt, M and Visser, M and Kritchevsky, S and Badinelli, S and Harris, T and Newman, AB and Cauley, J and Ferrucci, L and Guralnik, J (2011) Gait speed and survival in older adults. JAMA - Journal of the American Medical Association, 305 (1). 50 - 58. ISSN 0098-7484

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Abstract

Context: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates. Objective: To evaluate the relationship between gait speed and survival. Design, Setting, and Participants: Pooled analysis of 9 cohort studies (collected between 1986 and 2000), using individual data from 34 485 community-dwelling older adults aged 65 years or older with baseline gait speed data, followed up for 6 to 21 years. Participants were a mean (SD) age of 73.5 (5.9) years; 59.6%, women; and 79.8%, white; and had a mean (SD) gait speed of 0.92 (0.27) m/s. Main Outcome Measures: Survival rates and life expectancy. Results: There were 17 528 deaths; the overall 5-year survival rate was 84.8% (confidence interval [CI],79.6%-88.8%)and 10-year survival ratewas59.7%(95%CI,46.5%-70.6%). Gait speed was associated with survival in all studies (pooled hazard ratio per 0.1 m/s, 0.88; 95% CI, 0.87-0.90; P<.001). Survival increased across the full range of gait speeds, with significant increments per 0.1 m/s. At age 75, predicted 10-year survival across the range of gait speeds ranged from 19% to 87% in menand from35% to 91% in women. Predicted survival based on age, sex, and gait speed was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function or as age, sex, chronic conditions, smoking history, blood pressure, body mass index, and hospitalization. Conclusion: In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults. ©2011 American Medical Association. All rights reserved.


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Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Studenski, S
Perera, Sksp9@pitt.eduKSP9
Patel, K
Rosano, CRosanoC@edc.pitt.eduCAR2350
Faulkner, K
Inzitari, M
Brach, Jjbrach@pitt.eduJBRACH0000-0002-7793-2004
Chandler, J
Cawthon, P
Connor, EB
Nevitt, M
Visser, M
Kritchevsky, S
Badinelli, S
Harris, T
Newman, ABANEWMAN@pitt.eduANEWMAN
Cauley, JJCauley@edc.pitt.eduJCAULEY
Ferrucci, L
Guralnik, J
Date: 5 January 2011
Date Type: Publication
Journal or Publication Title: JAMA - Journal of the American Medical Association
Volume: 305
Number: 1
Page Range: 50 - 58
DOI or Unique Handle: 10.1001/jama.2010.1923
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0098-7484
Date Deposited: 02 Apr 2015 22:43
Last Modified: 18 Sep 2021 04:55
URI: http://d-scholarship.pitt.edu/id/eprint/24108

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