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Interpretation and use of FRAX in clinical practice

Kanis, JA and Hans, D and Cooper, C and Baim, S and Bilezikian, JP and Binkley, N and Cauley, JA and Compston, JE and Dawson-Hughes, B and El-Hajj Fuleihan, G and Johansson, H and Leslie, WD and Lewiecki, EM and Luckey, M and Oden, A and Papapoulos, SE and Poiana, C and Rizzoli, R and Wahl, DA and McCloskey, EV (2011) Interpretation and use of FRAX in clinical practice. Osteoporosis International, 22 (9). 2395 - 2411. ISSN 0937-941X

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Summary: The introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review Introduction: The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review. Methods: This study reviews the resource documents and joint position statements of ISCD and IOF. Results: Details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available. Conclusions: The wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice. © 2011 International Osteoporosis Foundation and National Osteoporosis Foundation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kanis, JA
Hans, D
Cooper, C
Baim, S
Bilezikian, JP
Binkley, N
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Compston, JE
Dawson-Hughes, B
El-Hajj Fuleihan, G
Johansson, H
Leslie, WD
Lewiecki, EM
Luckey, M
Oden, A
Papapoulos, SE
Poiana, C
Rizzoli, R
Wahl, DA
McCloskey, EV
Date: 1 September 2011
Date Type: Publication
Journal or Publication Title: Osteoporosis International
Volume: 22
Number: 9
Page Range: 2395 - 2411
DOI or Unique Handle: 10.1007/s00198-011-1713-z
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0937-941X
Date Deposited: 03 Apr 2015 16:35
Last Modified: 02 Feb 2019 15:55


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