Slinin, Y and Paudel, ML and Taylor, BC and Fink, HA and Ishani, A and Canales, MT and Yaffe, K and Barrett-Connor, E and Orwoll, ES and Shikany, JM and Leblanc, ES and Cauley, JA and Ensrud, KE
(2010)
25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men.
Neurology, 74 (1).
33 - 41.
ISSN 0028-3878
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Abstract
OBJECTIVE: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. METHODS: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function. RESULTS: In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81-4.19 for quartile [Q] 1; 1.41, 0.61-3.28 for Q2; and 1.18, 0.50-2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98-2.82 for Q1; 0.96, 0.54-1.69 for Q2; and 1.30, 0.76-2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH)D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89-2.23 for Q1; 1.28, 0.84-1.95 for Q2; and 1.06, 0.70-1.62 for Q3, compared with Q4 [p = 0.10]), but no association with cognitive decline by Trails B. CONCLUSION: We found little evidence of independent associations between lower 25-hydroxyvitamin D level and baseline global and executive cognitive function or incident cognitive decline. © 2010 by AAN Enterprises, Inc.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Slinin, Y | | | | Paudel, ML | | | | Taylor, BC | | | | Fink, HA | | | | Ishani, A | | | | Canales, MT | | | | Yaffe, K | | | | Barrett-Connor, E | | | | Orwoll, ES | | | | Shikany, JM | | | | Leblanc, ES | | | | Cauley, JA | JCauley@edc.pitt.edu | JCAULEY | | Ensrud, KE | | | |
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Date: |
1 January 2010 |
Date Type: |
Publication |
Journal or Publication Title: |
Neurology |
Volume: |
74 |
Number: |
1 |
Page Range: |
33 - 41 |
DOI or Unique Handle: |
10.1212/wnl.0b013e3181c7197b |
Schools and Programs: |
Graduate School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
0028-3878 |
Date Deposited: |
05 Aug 2015 18:24 |
Last Modified: |
02 Feb 2019 16:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24120 |
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