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25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men

Slinin, Y and Paudel, ML and Taylor, BC and Fink, HA and Ishani, A and Canales, MT and Yaffe, K and Barrett-Connor, E and Orwoll, ES and Shikany, JM and Leblanc, ES and Cauley, JA and Ensrud, KE (2010) 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology, 74 (1). 33 - 41. ISSN 0028-3878

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OBJECTIVE: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. METHODS: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function. RESULTS: In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81-4.19 for quartile [Q] 1; 1.41, 0.61-3.28 for Q2; and 1.18, 0.50-2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98-2.82 for Q1; 0.96, 0.54-1.69 for Q2; and 1.30, 0.76-2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH)D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89-2.23 for Q1; 1.28, 0.84-1.95 for Q2; and 1.06, 0.70-1.62 for Q3, compared with Q4 [p = 0.10]), but no association with cognitive decline by Trails B. CONCLUSION: We found little evidence of independent associations between lower 25-hydroxyvitamin D level and baseline global and executive cognitive function or incident cognitive decline. © 2010 by AAN Enterprises, Inc.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Slinin, Y
Paudel, ML
Taylor, BC
Fink, HA
Ishani, A
Canales, MT
Yaffe, K
Barrett-Connor, E
Orwoll, ES
Shikany, JM
Leblanc, ES
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Ensrud, KE
Date: 1 January 2010
Date Type: Publication
Journal or Publication Title: Neurology
Volume: 74
Number: 1
Page Range: 33 - 41
DOI or Unique Handle: 10.1212/wnl.0b013e3181c7197b
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0028-3878
Date Deposited: 05 Aug 2015 18:24
Last Modified: 02 Feb 2019 16:56


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