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Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men

Cawthon, PM and Parimi, N and Barrett-Connor, E and Laughlin, GA and Ensrud, KE and Hoffman, AR and Shikany, JM and Cauley, JA and Lane, NE and Bauer, DC and Orwoll, ES and Cummings, SR (2010) Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men. Journal of Clinical Endocrinology and Metabolism, 95 (10). 4625 - 4634. ISSN 0021-972X

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Context: Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults. Objective: The aim of the study was to test the association between 25(OH)D, PTH, and mortality in older men. Design and Setting: The prospective Osteoporotic Fractures in Men (MrOS) study was conducted at six U.S. clinical centers. Participants: We studied community-dwelling men at least 65 yr old (n = 1490). Main Outcome Measure: Multivariate-adjusted proportional hazards models estimated the hazard ratio (HR) for mortality; cause of death was classified as cancer, cardiovascular, and other by central review of death certificates. Results: During 7.3 yr of follow-up, 330 (22.2%) participants died: 97 from cancer, 110 from cardiovascular disease, and 106 from other causes. The adjusted HR per SD decrease in 25(OH)D for all-cause mortality was 1.01 (95% CI, 0.89, 1.14); no association between 25(OH)D and cardiovascular or other-cause mortality was seen. Unexpectedly, lower 25(OH)D levels were modestly associated with a decreased risk of cancer mortality (adjusted HR per SD decrease, 0.80; 95% CI, 0.64, 0.99). Analyzing 25(OH)D as a categorical variable did not alter these results. Higher PTH levels (log-transformed) were associated with an increased risk of all-cause mortality (adjusted HR per SD increase, 1.15; 95% CI, 1.03, 1.29) and cardiovascular mortality (adjusted HR per SD increase in PTH, 1.21; 95% CI, 1.00, 1.45). Conclusions: In contrast to previous studies, lower 25(OH)D levels were not associated with an increased risk of all-cause or cause-specific mortality in older men. Higher PTH levels were associated with a modest increase in mortality risk. Copyright © 2010 by The Endocrine Society.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Cawthon, PM
Parimi, N
Barrett-Connor, E
Laughlin, GA
Ensrud, KE
Hoffman, AR
Shikany, JM
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Lane, NE
Bauer, DC
Orwoll, ES
Cummings, SR
Date: 1 January 2010
Date Type: Publication
Journal or Publication Title: Journal of Clinical Endocrinology and Metabolism
Volume: 95
Number: 10
Page Range: 4625 - 4634
DOI or Unique Handle: 10.1210/jc.2010-0638
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0021-972X
Date Deposited: 12 May 2015 19:58
Last Modified: 04 Feb 2019 20:55


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