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Bone mass and strength in older men with type 2 diabetes: The osteoporotic fractures in men study

Petit, MA and Paudel, ML and Taylor, BC and Hughes, JM and Strotmeyer, ES and Schwartz, AV and Cauley, JA and Zmuda, JM and Hoffman, AR and Ensrud, KE (2010) Bone mass and strength in older men with type 2 diabetes: The osteoporotic fractures in men study. Journal of Bone and Mineral Research, 25 (2). 285 - 291. ISSN 0884-0431

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The effects of type 2 diabetes mellitus (T2DM) on bone volumetric density, bone geometry, and estimates of bone strength are not well established. We used peripheral quantitative computed tomography (pQCT) to compare tibial and radial bone volumetric density (vBMD, mg/cm<sup>3</sup>), total (ToA, mm<sup>2</sup>) and cortical (CoA, mm<sup>2</sup>) bone area and estimates of bone compressive and bending strength in a subset (n=1171) of men (≥65 years of age) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study. Analysis of covariance-adjusted bone data for clinic site, age, and limb length (model 1) and further adjusted for body weight (model 2) were used to compare data between participants with (n=190) and without (n=981) T2DM. At both the distal tibia and radius, patients with T2DM had greater bone vBMD (+2% to +4%, model 1, p<.05) and a smaller bone area (ToA -1% to -4%, model 2, p<.05). The higher vBMD compensated for lower bone area, resulting in no differences in estimated compressive bone strength at the distal trabecular bone regions. At the mostly cortical bone midshaft sites of the radius and tibia, men with T2DM had lower ToA (-1% to -3%, p<.05), resulting in lower bone bending strength at both sites after adjusting for body weight (-2% to -5%, p<.05) despite the lack of difference in cortical vBMD at these sites. These data demonstrate that older men with T2DM have bone strength that is low relative to body weight at the cortical-rich midshaft of the radius despite no difference in cortical vBMD. © 2010 American Society for Bone and Mineral Research.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Petit, MA
Paudel, ML
Taylor, BC
Hughes, JM
Strotmeyer, ESstrotmeyere@edc.pitt.eduELSST21
Schwartz, AV
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Zmuda, JMZmudaJ@edc.pitt.eduEPIDJMZ
Hoffman, AR
Ensrud, KE
Date: 1 January 2010
Date Type: Publication
Journal or Publication Title: Journal of Bone and Mineral Research
Volume: 25
Number: 2
Page Range: 285 - 291
DOI or Unique Handle: 10.1359/jbmr.090725
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0884-0431
Date Deposited: 03 Apr 2015 21:06
Last Modified: 02 Feb 2019 16:56


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