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Adipokines and the risk of fracture in older adults

Barbour, KE and Zmuda, JM and Boudreau, R and Strotmeyer, ES and Horwitz, MJ and Evans, RW and Kanaya, AM and Harris, TB and Bauer, DC and Cauley, JA (2011) Adipokines and the risk of fracture in older adults. Journal of Bone and Mineral Research, 26 (7). 1568 - 1576. ISSN 0884-0431

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Adiponectin and leptin are adipokines that influence bone metabolism in vitro and in animal models. However, less is known about the longitudinal association of leptin and adiponectin with fracture. We tested the hypothesis that low leptin and high adiponectin levels are each individually associated with fracture risk in a prospective cohort study in Memphis and Pittsburgh among 3075 women and men aged 70 to 79 years from the Health Aging and Body Composition (Health ABC) study. There were 406 incident fractures (334 nonvertebral and 72 vertebral) over a mean of 6.5 ± 1.9 years. Cox regression was used to estimate the hazard ratios for fracture. Sex modified the association between adiponectin and fracture (p = .025 for interaction). Men with the highest adiponectin level (tertile 3) had a 94% higher risk of fracture [hazard ratio (HR) = 1.94; 95% confidence interval (CI) 1.20-3.16] compared with the lowest tertile (tertile 1; p = .007 for trend) after adjusting age, race, body mass index (BMI), education, diabetes, weight change, and hip bone mineral density (BMD). Among women, after adjusting for age and race, this association was no longer significant (p = .369 for trend). Leptin did not predict fracture risk in women (p = .544 for trend) or men (p = .118 for trend) in the multivariate models. Our results suggest that adiponectin, but not leptin, may be a novel risk factor for increased fracture risk independent of body composition and BMD and that these relationships may be influenced by sex. More research is needed to understand the physiologic basis underlying these sex differences. Copyright © 2011 American Society for Bone and Mineral Research.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Barbour, KE
Zmuda, JMZmudaJ@edc.pitt.eduEPIDJMZ
Boudreau, RBoudreauR@edc.pitt.eduROB21
Strotmeyer, ESstrotmeyere@edc.pitt.eduELSST21
Horwitz, MJ
Evans, RWEvansR@edc.pitt.eduRWE2
Kanaya, AM
Harris, TB
Bauer, DC
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Date: 1 July 2011
Date Type: Publication
Journal or Publication Title: Journal of Bone and Mineral Research
Volume: 26
Number: 7
Page Range: 1568 - 1576
DOI or Unique Handle: 10.1002/jbmr.361
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0884-0431
Date Deposited: 03 Apr 2015 16:49
Last Modified: 05 Feb 2019 11:55


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