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Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults?

Koster, A and Ding, J and Stenholm, S and Caserotti, P and Houston, DK and Nicklas, BJ and You, T and Lee, JS and Visser, M and Newman, AB and Schwartz, AV and Cauley, JA and Tylavsky, FA and Goodpaster, BH and Kritchevsky, SB and Harris, TB (2011) Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults? Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 66 A (8). 888 - 895. ISSN 1079-5006

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Abstract

Background. An excessive amount of adipose tissue may contribute to sarcopenia and may be one mechanism underlying accelerated loss of muscle mass and strength with aging. We therefore examined the association of baseline total body fat with changes in leg lean mass, muscle strength, and muscle quality over 7 years of follow-up and whether this link was explained by adipocytokines and insulin resistance. Methods. Data were from 2,307 men and women, aged 70-79 years, participating in the Health, Aging, and Body Composition study. Total fat mass was acquired from dual energy X-ray absorptiometry. Leg lean mass was assessed by dual energy X-ray absorptiometry in Years 1, 2, 3, 4, 5, 6, and 8. Knee extension strength was measured by isokinetic dynamometer in Years 1, 2, 4, 6, and 8. Muscle quality was calculated as muscle strength divided by leg lean mass. Results. Every SD greater fat mass was related to 1.3 kg more leg lean mass at baseline in men and 1.5 kg in women (p < .01). Greater fat mass was also associated with a greater decline in leg lean mass in both men and women (0.02 kg/year, p < .01), which was not explained by higher levels of adipocytokines and insulin resistance. Larger fat mass was related to significantly greater muscle strength but significantly lower muscle quality at baseline (p < .01). No significant differences in decline of muscle strength and quality were found. Conclusions. High fatness was associated with lower muscle quality, and it predicts accelerated loss of lean mass. Prevention of greater fatness in old age may decrease the loss of lean mass and maintain muscle quality and thereby reducing disability and mobility impairments. © The Author 2011. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.


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Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Koster, A
Ding, J
Stenholm, S
Caserotti, P
Houston, DK
Nicklas, BJ
You, T
Lee, JS
Visser, M
Newman, ABANEWMAN@pitt.eduANEWMAN
Schwartz, AV
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Tylavsky, FA
Goodpaster, BHbgood@pitt.eduBGOOD
Kritchevsky, SB
Harris, TB
Date: 1 August 2011
Date Type: Publication
Journal or Publication Title: Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume: 66 A
Number: 8
Page Range: 888 - 895
DOI or Unique Handle: 10.1093/gerona/glr070
Schools and Programs: Graduate School of Public Health > Epidemiology
School of Medicine > Medicine
Refereed: Yes
ISSN: 1079-5006
Date Deposited: 03 Apr 2015 16:32
Last Modified: 22 May 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/24218

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