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Evidence for geographical and racial variation in serum sex steroid levels in older men

Orwoll, ES and Nielson, CM and Labrie, F and Barrett-Connor, E and Cauley, JA and Cummings, SR and Ensrud, K and Karlsson, M and Lau, E and Leung, PC and Lunggren, O and Mellström, D and Patrick, AL and Stefanick, ML and Nakamura, K and Yoshimura, N and Zmuda, J and Vandenput, L and Ohlsson, C (2010) Evidence for geographical and racial variation in serum sex steroid levels in older men. Journal of Clinical Endocrinology and Metabolism, 95 (10). ISSN 0021-972X

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Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass spectrometry, concentrations of serum androgens, estrogens, and sex steroid precursors/metabolites were measured in 5003 older men from five countries. SHBG levels were assessed using radioimmunoassay. Results: There was substantial geographical variation in the levels of sex steroids, precursors, and metabolites, as well as SHBG. For instance, Asian men in Hong Kong and Japan, but not in the United States, had levels of total testosterone approximately 20% higher than in other groups. Even greater variation was present in levels of estradiol, SHBG, and dihydrotestosterone. Group differences in body mass index did not explain most geographical differences. In addition, body mass index-independent racial differences were present; Black men had higher levels of estrogens (estradiol, estrone), and Asian men had lower levels of glucuronidated androgen metabolites. Conclusions: On a global scale, there are important geographical and racial differences in the concentrations of serum sex steroids and SHBG in older men. Copyright © 2010 by The Endocrine Society.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Orwoll, ES
Nielson, CM
Labrie, F
Barrett-Connor, E
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Cummings, SR
Ensrud, K
Karlsson, M
Lau, E
Leung, PC
Lunggren, O
Mellström, D
Patrick, AL
Stefanick, ML
Nakamura, K
Yoshimura, N
Zmuda, JZmudaJ@edc.pitt.eduEPIDJMZ
Vandenput, L
Ohlsson, C
Date: 1 January 2010
Date Type: Publication
Journal or Publication Title: Journal of Clinical Endocrinology and Metabolism
Volume: 95
Number: 10
DOI or Unique Handle: 10.1210/jc.2009-2435
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0021-972X
Date Deposited: 23 Nov 2015 20:11
Last Modified: 04 Feb 2019 20:55


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