Ensrud, KE and Blackwell, TL and Cauley, JA and Cummings, SR and Barrett-Connor, E and Dam, TTL and Hoffman, AR and Shikany, JM and Lane, NE and Stefanick, ML and Orwoll, ES and Cawthon, PM
(2011)
Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study.
Journal of the American Geriatrics Society, 59 (1).
101 - 106.
ISSN 0002-8614
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Abstract
OBJECTIVES: To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. community-based centers. PARTICIPANTS: One thousand six hundred six men aged 65 and older. MEASUREMENTS: 25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS: After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION: Lower levels of 25(OH)D (<20.0 ng/mL) in community-dwelling older men were independently associated with greater evidence of frailty at baseline but did not predict greater risk of greater frailty status at 4.6 years. © 2010, The American Geriatrics Society.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Ensrud, KE | | | | Blackwell, TL | | | | Cauley, JA | JCauley@edc.pitt.edu | JCAULEY | | Cummings, SR | | | | Barrett-Connor, E | | | | Dam, TTL | | | | Hoffman, AR | | | | Shikany, JM | | | | Lane, NE | | | | Stefanick, ML | | | | Orwoll, ES | | | | Cawthon, PM | | | |
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Date: |
1 January 2011 |
Date Type: |
Publication |
Journal or Publication Title: |
Journal of the American Geriatrics Society |
Volume: |
59 |
Number: |
1 |
Page Range: |
101 - 106 |
DOI or Unique Handle: |
10.1111/j.1532-5415.2010.03201.x |
Schools and Programs: |
Graduate School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
0002-8614 |
Date Deposited: |
01 Dec 2015 15:03 |
Last Modified: |
30 Oct 2018 13:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24221 |
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