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Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study

Ensrud, KE and Blackwell, TL and Cauley, JA and Cummings, SR and Barrett-Connor, E and Dam, TTL and Hoffman, AR and Shikany, JM and Lane, NE and Stefanick, ML and Orwoll, ES and Cawthon, PM (2011) Circulating 25-hydroxyvitamin D levels and frailty in older men: The osteoporotic fractures in men study. Journal of the American Geriatrics Society, 59 (1). 101 - 106. ISSN 0002-8614

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OBJECTIVES: To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. community-based centers. PARTICIPANTS: One thousand six hundred six men aged 65 and older. MEASUREMENTS: 25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up. RESULTS: After adjusting for multiple potential confounders, men with 25(OH)D levels less than 20.0 ng/mL had 1.5 times higher odds (multivariate odds ratio (MOR)=1.47, 95% confidence interval (CI)=1.07-2.02) of greater frailty status at baseline than men with 25(OH)D levels of 30.0 ng/mL or greater (referent group), whereas frailty status was similar in men with 25(OH)D levels from 20.0 to 29.9 ng/mL and those with levels of 30.0 ng/mL or greater (MOR=1.02, 95% CI=0.78-1.32). However, in 1,267 men not classified as frail at baseline, there was no association between lower baseline 25(OH)D level and odds of greater frailty status at the 4.6-year follow-up. Findings were the same when 25(OH)D was expressed in quartiles or as a continuous variable. CONCLUSION: Lower levels of 25(OH)D (<20.0 ng/mL) in community-dwelling older men were independently associated with greater evidence of frailty at baseline but did not predict greater risk of greater frailty status at 4.6 years. © 2010, The American Geriatrics Society.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ensrud, KE
Blackwell, TL
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Cummings, SR
Barrett-Connor, E
Dam, TTL
Hoffman, AR
Shikany, JM
Lane, NE
Stefanick, ML
Orwoll, ES
Cawthon, PM
Date: 1 January 2011
Date Type: Publication
Journal or Publication Title: Journal of the American Geriatrics Society
Volume: 59
Number: 1
Page Range: 101 - 106
DOI or Unique Handle: 10.1111/j.1532-5415.2010.03201.x
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0002-8614
Date Deposited: 01 Dec 2015 15:03
Last Modified: 30 Oct 2018 13:56


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