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Sex steroid hormones in older men: Longitudinal associations with 4.5-year change in hip bone mineral density - The osteoporotic fractures in men study

Cauley, JA and Ewing, SK and Taylor, BC and Fink, HA and Ensrud, KE and Bauer, DC and Barrett-Connor, E and Marshall, L and Orwoll, ES (2010) Sex steroid hormones in older men: Longitudinal associations with 4.5-year change in hip bone mineral density - The osteoporotic fractures in men study. Journal of Clinical Endocrinology and Metabolism, 95 (9). 4314 - 4323. ISSN 0021-972X

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Context: There is limited information on the association between sex hormones and bone loss in older men. Objective: Our objective was to determine the longitudinal association between sex steroid hormones and bone mineral density (BMD). Design and Setting: We conducted a prospective study of 5995 men aged at least 65 yr old at six U.S. clinical centers. Participants: Sex steroid hormones were measured in a random sample of 1602 men. After exclusions, 1238 men were included in cross-sectional analyses and 969 in longitudinal analyses. Baseline sex hormones were measured using liquid chromatography-mass spectrometry. Bioavailable (Bio) estradiol (BioE2) and testosterone (BioT) were calculated from mass action equations. SHBG was measured using chemiluminescent substrate. Main Outcome Measures: BMD of the total hip, measured at baseline and once or twice afterward over 4.6 yr of follow-up, was evaluated. Results: The annualized percent change in hip BMD increased with decreasing BioE2 (P trend = 0.03). Men with the lowest BioE2 (<39.7 pmol/liter) compared with the highest BioE2 (≥66.0 pmol/liter) experienced 38% faster rate of BMD loss (P < 0.05). There was no association between BioT and hip BMD loss. Men with lowest BioE2, lowest BioT, and highest SHBG experienced a 3-fold faster rate of BMD loss compared withmenwith higher levels (P=0.02). A threshold effect of SHBG was observed; the rate of hip BMD loss increased in men with SHBG of 49-60 nM. Conclusions: Low BioE2 and high SHBG levels were associated with lower BMD and faster hip BMD loss. The combination of low BioE2, low BioT, and high SHBG was associated with significantly faster rates of BMD loss. Copyright © 2010 by The Endocrine Society.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Ewing, SK
Taylor, BC
Fink, HA
Ensrud, KE
Bauer, DC
Barrett-Connor, E
Marshall, L
Orwoll, ES
Date: 1 January 2010
Date Type: Publication
Journal or Publication Title: Journal of Clinical Endocrinology and Metabolism
Volume: 95
Number: 9
Page Range: 4314 - 4323
DOI or Unique Handle: 10.1210/jc.2009-2635
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0021-972X
Date Deposited: 01 Dec 2015 15:36
Last Modified: 02 Feb 2019 16:56


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