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Fatty acid consumption and risk of fracture in the Women's Health Initiative

Orchard, TS and Cauley, JA and Frank, GC and Neuhouser, ML and Robinson, JG and Snetselaar, L and Tylavsky, F and Wactawski-Wende, J and Young, AM and Lu, B and Jackson, RD (2010) Fatty acid consumption and risk of fracture in the Women's Health Initiative. American Journal of Clinical Nutrition, 92 (6). 1452 - 1460. ISSN 0002-9165

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Background: Fatty acids (FAs) may be important dietary components that modulate osteoporotic fracture risk. Objective: The objective was to examine FA intake in relation to osteoporotic fractures. Design: The participants were postmenopausal women enrolled in the Women's Health Initiative (n = 137,486). Total fractures were identified by self-report; hip fractures were confirmed by medical record review. FA intake was estimated from baseline food-frequency questionnaires and standardized to total caloric intake. No data on omega-3 (n-3) FA supplements were available. Cox proportional hazard models were constructed to estimate risk of fracture. Results: Higher saturated FA consumption was associated with higher hip fracture risk [quartile 4 multivariate-adjusted hazard ratio (HR): 1.31; 95% CI: 1.11, 1.55; P for trend = 0.001]. Lower total fracture risk was associated with a higher monounsaturated FA intake (quartile 3 HR: 0.94; 95% CI: 0.89, 0.98; P for trend = 0.050) and polyunsaturated FA intake (quartile 4 HR: 0.95; 95% CI: 0.90, 0.99; P for trend = 0.019). Unexpectedly, higher consumption of marine n-3 FAs was associated with greater total fracture risk (quartile 4 HR: 1.07; 95% CI: 1.02, 1.12; P for trend = 0.010), whereas a higher n26 FA intake was associated with a lower total fracture risk (quartile 4 HR: 0.94; 95% CI: 0.89, 0.98; P for trend 0.009). Conclusions: These results suggest that saturated FA intake may significantly increase hip fracture risk, whereas monounsaturated and polyunsaturated FA intakes may decrease total fracture risk. In postmenopausal women with a low intake of marine n-3 FAs, a higher intake of n26 FAs may modestly decrease total fracture risk. This trial was registered at as NCT00000611. © 2010 American Society for Nutrition.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Orchard, TS
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Frank, GC
Neuhouser, ML
Robinson, JG
Snetselaar, L
Tylavsky, F
Wactawski-Wende, J
Young, AM
Lu, B
Jackson, RD
Date: 1 December 2010
Date Type: Publication
Journal or Publication Title: American Journal of Clinical Nutrition
Volume: 92
Number: 6
Page Range: 1452 - 1460
DOI or Unique Handle: 10.3945/ajcn.2010.29955
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0002-9165
Date Deposited: 23 Nov 2015 20:12
Last Modified: 27 Jan 2019 03:55


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