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Fish consumption, bone mineral density, and risk of hip fracture among older adults: The cardiovascular health study

Virtanen, JK and Mozaffarian, D and Cauley, JA and Mukamal, KJ and Robbins, J and Siscovick, DS (2010) Fish consumption, bone mineral density, and risk of hip fracture among older adults: The cardiovascular health study. Journal of Bone and Mineral Research, 25 (9). 1972 - 1979. ISSN 0884-0431

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Marine n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be beneficial for bone health, but few studies have investigated the association with fish consumption. Our aim was to study associations of fish and EPA+DHA consumption with bone mineral density (BMD) and hip fracture risk and determine whether high linoleic acid (LA) intake, the major dietary n-6 PUFA, modifies the associations. The study population consisted of 5045 participants aged 65 years and older from the Cardiovascular Health Study. Data on BMD were available for 1305 participants. Food-frequency questionnaire was used to assess dietary intake, and hip fracture incidence was assessed prospectively by review of hospitalization records. After multivariable adjustment, femoral neck BMD was 0.01 g/cm2 lower in the highest versus lowest tuna/other-fish intake category (p=.05 for trend). EPA+DHA intake (higher versus lower median of 0.32 g/day) was associated with lower femoral neck BMD (0.66 versus 0.71 g/cm2, p<.001) among those with LA intake greater than the median 12.1 g/day (p=.03 for interaction). No significant associations were found with total-hip BMD. During mean follow-up of 11.1 years, 505 hip fractures occurred. Fish or EPA+DHA consumption was not significantly associated with fracture incidence [hazard ratio (HR) for extreme categories: HR=1.23, 95% confidence interval (CI) 0.83-1.84 for tuna/other fish; HR=1.16, 95% CI 0.91-1.49 for fried fish; and HR=0.98, 95% CI 0.71-1.36 for EPA+DHA]. High LA intake did not modify these associations. In this large prospective cohort of older adults, fish consumption was associated with very small differences in BMD and had no association with hip fracture risk. © 2010 American Society for Bone and Mineral Research.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Virtanen, JK
Mozaffarian, D
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Mukamal, KJ
Robbins, J
Siscovick, DS
Date: 1 September 2010
Date Type: Publication
Journal or Publication Title: Journal of Bone and Mineral Research
Volume: 25
Number: 9
Page Range: 1972 - 1979
DOI or Unique Handle: 10.1002/jbmr.87
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0884-0431
Date Deposited: 03 Apr 2015 21:18
Last Modified: 22 Jun 2021 12:55


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