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The role of bone marrow and visceral fat on bone metabolism

Sheu, Y and Cauley, JA (2011) The role of bone marrow and visceral fat on bone metabolism. Current Osteoporosis Reports, 9 (2). 67 - 75. ISSN 1544-1873

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The protective effect of total fat mass on bone mineral density (BMD) has been challenged with studies showing no or negative association after adjusting for weight. Subsequently, more studies have evaluated the relationship of regional adiposity with BMD, and findings were inconsistent for central obesity. Advancements in imaging techniques enable us to directly and noninvasively study the role of adiposity on skeletal health. Visceral adiposity measured by computed tomography (CT) has consistently been shown to have negative effects on bone. Availability of magnetic resonance spectroscopy (MRS) also allows us to noninvasively quantify bone marrow fat (BMF), which has been known to be associated with osteoporosis from histomorphometric studies. Using MRS along with dual energy x-ray absorptiometry, studies have reported a detrimental role of BMF on BMD. With the increase in aging and obesity of the population, it is important to continue this effort in identifying the contribution of adipose tissues to bone quality and fracture. © 2011 Springer Science+Business Media, LLC.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Sheu, Yyas12@pitt.eduYAS12
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Date: 1 June 2011
Date Type: Publication
Journal or Publication Title: Current Osteoporosis Reports
Volume: 9
Number: 2
Page Range: 67 - 75
DOI or Unique Handle: 10.1007/s11914-011-0051-6
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1544-1873
Date Deposited: 03 Apr 2015 16:23
Last Modified: 25 Jan 2019 20:55


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