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COCAINE-BASED SIGNALING CHANGES IN THE NUCLEUS ACCUMBENS, LATERAL HABENULA, AND THALAMUS

Neumann, Peter Alaric (2015) COCAINE-BASED SIGNALING CHANGES IN THE NUCLEUS ACCUMBENS, LATERAL HABENULA, AND THALAMUS. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

The brain is an extraordinarily complex and organized system. Environmental information reaches the brain via the sensory systems, and this information is processed to interpret and make sense of the world. The mechanisms used to transmit information between neurons are also involved in directing and modifying the strength of these connections. Thus, the brain is always in a plastic state and has the ability to both interpret neural information and be shaped by it. Cocaine addiction is a progressive condition highlighted by maladaptive and compulsive behavior that develops after exposure to cocaine. Thus, cocaine exposure changes neural processing in the brain in ways that lead to the addicted state. The work presented here examines how neural circuits in addiction-related brain regions, such as those involved in motivated behavior and translating emotion into action, change at the cellular and molecular levels in response to cocaine exposure. The results uncover a variety of novel cocaine-induced changes in neural circuitry and processing which likely contribute to the development and/or maintenance of addiction.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Neumann, Peter Alaricpan23@pitt.eduPAN23
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairDong, Yanyandong@pitt.eduYANDONG
Committee MemberSesack, Susansesack@pitt.eduSESACK
Committee MemberCard, J. Patrickcard@pitt.eduCARD
Committee MemberMcClung, Colleen A.mcclungc@pitt.eduMCCLUNGC
Committee MemberGrace, Anthony AGraceAA@pitt.eduGRACEAA
Committee MemberMalenka, Robmalenka@stanford.edu
Date: 22 June 2015
Date Type: Publication
Defense Date: 20 January 2015
Approval Date: 22 June 2015
Submission Date: 30 March 2015
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Number of Pages: 148
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: cocaine addiction plasticity
Date Deposited: 22 Jun 2015 16:29
Last Modified: 15 Nov 2016 14:26
URI: http://d-scholarship.pitt.edu/id/eprint/24246

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