Eastell, R and Lang, T and Boonen, S and Cummings, S and Delmas, PD and Cauley, JA and Horowitz, Z and Kerzberg, E and Bianchi, G and Kendler, D and Leung, P and Man, Z and Mesenbrink, P and Eriksen, EF and Black, DM
(2010)
Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: Results of the HORIZON pivotal fracture trial.
Osteoporosis International, 21 (7).
1277 - 1285.
ISSN 0937-941X
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Abstract
Summary: Changes in bone mineral density and bone strength following treatment with zoledronic acid (ZOL) were measured by quantitative computed analysis (QCT) or dual-energy X-ray absorptiometry (DXA). ZOL treatment increased spine and hip BMD vs placebo, assessed by QCT and DXA. Changes in trabecular bone resulted in increased bone strength. Introduction: To investigate bone mineral density (BMD) changes in trabecular and cortical bone, estimated by quantitative computed analysis (QCT) or dual-energy X-ray absorptiometry (DXA), and whether zoledronic acid 5 mg (ZOL) affects bone strength. Methods: In 233 women from a randomized, controlled trial of once-yearly ZOL, lumbar spine, total hip, femoral neck, and trochanter were assessed by DXA and QCT (baseline, Month 36). Mean percentage changes from baseline and between-treatment differences (ZOL vs placebo, t-test) were evaluated. Results: Mean between-treatment differences for lumbar spine BMD were significant by DXA (7.0%, p<0.01) and QCT (5.7%, p<0.0001). Between-treatment differences were significant for trabecular spine (p=0.0017) [non-parametric test], trabecular trochanter (10.7%, p<0.0001), total hip (10.8%, p<0.0001), and compressive strength indices at femoral neck (8.6%, p=0.0001), and trochanter (14.1%, p<0.0001). Conclusions: Once-yearly ZOL increased hip and spine BMD vs placebo, assessed by QCT vs DXA. Changes in trabecular bone resulted in increased indices of compressive strength. © International Osteoporosis Foundation and National Osteoporosis Foundation 2009.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Eastell, R | | | | Lang, T | | | | Boonen, S | | | | Cummings, S | | | | Delmas, PD | | | | Cauley, JA | JCauley@edc.pitt.edu | JCAULEY | | Horowitz, Z | | | | Kerzberg, E | | | | Bianchi, G | | | | Kendler, D | | | | Leung, P | | | | Man, Z | | | | Mesenbrink, P | | | | Eriksen, EF | | | | Black, DM | | | |
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Date: |
1 July 2010 |
Date Type: |
Publication |
Journal or Publication Title: |
Osteoporosis International |
Volume: |
21 |
Number: |
7 |
Page Range: |
1277 - 1285 |
DOI or Unique Handle: |
10.1007/s00198-009-1077-9 |
Schools and Programs: |
Graduate School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
0937-941X |
Date Deposited: |
01 Dec 2015 15:07 |
Last Modified: |
04 Feb 2019 20:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24252 |
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