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Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: Results of the HORIZON pivotal fracture trial

Eastell, R and Lang, T and Boonen, S and Cummings, S and Delmas, PD and Cauley, JA and Horowitz, Z and Kerzberg, E and Bianchi, G and Kendler, D and Leung, P and Man, Z and Mesenbrink, P and Eriksen, EF and Black, DM (2010) Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: Results of the HORIZON pivotal fracture trial. Osteoporosis International, 21 (7). 1277 - 1285. ISSN 0937-941X

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Abstract

Summary: Changes in bone mineral density and bone strength following treatment with zoledronic acid (ZOL) were measured by quantitative computed analysis (QCT) or dual-energy X-ray absorptiometry (DXA). ZOL treatment increased spine and hip BMD vs placebo, assessed by QCT and DXA. Changes in trabecular bone resulted in increased bone strength. Introduction: To investigate bone mineral density (BMD) changes in trabecular and cortical bone, estimated by quantitative computed analysis (QCT) or dual-energy X-ray absorptiometry (DXA), and whether zoledronic acid 5 mg (ZOL) affects bone strength. Methods: In 233 women from a randomized, controlled trial of once-yearly ZOL, lumbar spine, total hip, femoral neck, and trochanter were assessed by DXA and QCT (baseline, Month 36). Mean percentage changes from baseline and between-treatment differences (ZOL vs placebo, t-test) were evaluated. Results: Mean between-treatment differences for lumbar spine BMD were significant by DXA (7.0%, p<0.01) and QCT (5.7%, p<0.0001). Between-treatment differences were significant for trabecular spine (p=0.0017) [non-parametric test], trabecular trochanter (10.7%, p<0.0001), total hip (10.8%, p<0.0001), and compressive strength indices at femoral neck (8.6%, p=0.0001), and trochanter (14.1%, p<0.0001). Conclusions: Once-yearly ZOL increased hip and spine BMD vs placebo, assessed by QCT vs DXA. Changes in trabecular bone resulted in increased indices of compressive strength. © International Osteoporosis Foundation and National Osteoporosis Foundation 2009.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Eastell, R
Lang, T
Boonen, S
Cummings, S
Delmas, PD
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Horowitz, Z
Kerzberg, E
Bianchi, G
Kendler, D
Leung, P
Man, Z
Mesenbrink, P
Eriksen, EF
Black, DM
Date: 1 July 2010
Date Type: Publication
Journal or Publication Title: Osteoporosis International
Volume: 21
Number: 7
Page Range: 1277 - 1285
DOI or Unique Handle: 10.1007/s00198-009-1077-9
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0937-941X
Date Deposited: 01 Dec 2015 15:07
Last Modified: 04 Feb 2019 20:55
URI: http://d-scholarship.pitt.edu/id/eprint/24252

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