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Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials

Cecchini, RS and Costantino, JP and Cauley, JA and Cronin, WM and Wickerham, DL and Land, SR and Weissfeld, JL and Wolmark, N (2012) Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials. Cancer Prevention Research, 5 (4). 583 - 592. ISSN 1940-6207

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High body mass index (BMI) has been associated with an increased risk for breast cancer among postmenopausal women. However, the relationship between BMI and breast cancer risk in premenopausal women has remained unclear. Data from two large prevention trials conducted by the National Surgical Adjuvant Breast and Bowel Project (NSABP) were used to explore the relationship between baseline BMI and breast cancer risk. The analyses included 12,243 participants with 253 invasive breast cancer events from the Breast Cancer Prevention Trial (P-1) and 19,488 participants with 557 events from the Study of Tamoxifen and Raloxifene (STAR). Both studies enrolled high-risk women (Gail score ≥ 1.66) with no breast cancer history. Women in P-1 were pre-and postmenopausal, whereas women in STAR (P-2) were all postmenopausal at entry. Using Cox proportional hazards regression, we found slight but nonsignificant increased risks of invasive breast cancer among overweight and obese postmenopausal participants in STAR and P-1. Among premenopausal participants, an increased risk of invasive breast cancer was significantly associated with higher BMI (P = 0.01). Compared with BMI less than 25, adjusted HRs for premenopausal women were 1.59 for BMI 25 to 29.9 and 1.70 for BMI 30 or more. Our investigation among annually screened, high-risk participants in randomized, breast cancer chemoprevention trials showed that higher levels of BMI were significantly associated with increased breast cancer risk in premenopausal women older than 35 years, but not postmenopausal women. ©2012 AACR.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Cecchini, RSrls18@pitt.eduRLS180000-0002-9075-9357
Costantino, JPcostan@pitt.eduCOSTAN0000-0002-0049-7219
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Cronin, WMcronin1@pitt.eduCRONIN1
Wickerham, DL
Land, SR
Weissfeld, JL
Wolmark, N
Date: 1 April 2012
Date Type: Publication
Journal or Publication Title: Cancer Prevention Research
Volume: 5
Number: 4
Page Range: 583 - 592
DOI or Unique Handle: 10.1158/1940-6207.capr-11-0482
Schools and Programs: School of Public Health > Biostatistics
School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1940-6207
Date Deposited: 03 Apr 2015 01:19
Last Modified: 02 Feb 2019 15:55


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