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Twenty-year depressive trajectories among older women

Byers, AL and Vittinghoff, E and Lui, LY and Hoang, T and Blazer, DG and Covinsky, KE and Ensrud, KE and Cauley, JA and Hillier, TA and Fredman, L and Yaffe, K (2012) Twenty-year depressive trajectories among older women. Archives of General Psychiatry, 69 (10). 1073 - 1079. ISSN 0003-990X

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Context: Despite the frequent occurrence of depressive symptoms among older adults, especially women, little is known about the long-term course of late-life depressive symptoms. Objective: To characterize the natural course of depressive symptoms among older women (from the young old to the oldest old) followed up for almost 20 years. Design: Using latent-class growth-curve analysis, we analyzed women enrolled in an ongoing prospective cohort study (1988 through 2009). Setting: Clinic sites in Baltimore, Maryland; Minneapolis, Minnesota; the Monongahela Valley near Pittsburgh, Pennsylvania; and Portland, Oregon. Participants: We studied 7240 community-dwelling women 65 years or older. Main Outcome Measure: The Geriatric Depression Scale short form (score range, 0-15) was used to routinely assess depressive symptoms during the follow-up period. Results: Among older women, we identified 4 latent classes during 20 years, with the predicted probabilities of group membership totaling 27.8% with minimal depressive symptoms, 54.0% with persistently low depressive symptoms, 14.8% with increasing depressive symptoms, and 3.4% with persistently high depressive symptoms. In an adjusted model for latent class membership, odds ratios (ORs) for belonging in the increasing depressive symptoms and persistently high depressive symptoms classes, respectively, compared with a group having minimal depressive symptoms were substantially and significantly (P < .05) elevated for the following variables: baseline smoking (ORs, 4.69 and 7.97), physical inactivity (ORs, 2.11 and 2.78), small social network (ORs, 3.24 and 6.75), physical impairment (ORs, 8.11 and 16.43), myocardial infarction (ORs, 2.09 and 2.41), diabetes mellitus (ORs, 2.98 and 3.03), and obesity (ORs, 1.86 and 2.90). Conclusions: During 20 years, almost 20% of older women experienced persistently high depressive symptoms or increasing depressive symptoms. In addition, these women had more comorbidities, physical impairment, and negative lifestyle factors at baseline. These associations support the need for intervention and prevention strategies to reduce depressive symptoms into the oldest-old years. ©2012 American Medical Association. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Byers, AL
Vittinghoff, E
Lui, LY
Hoang, T
Blazer, DG
Covinsky, KE
Ensrud, KE
Cauley, JAJCauley@edc.pitt.eduJCAULEY
Hillier, TA
Fredman, L
Yaffe, K
Date: 1 October 2012
Date Type: Publication
Journal or Publication Title: Archives of General Psychiatry
Volume: 69
Number: 10
Page Range: 1073 - 1079
DOI or Unique Handle: 10.1001/archgenpsychiatry.2012.43
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0003-990X
Date Deposited: 03 Apr 2015 00:52
Last Modified: 02 Feb 2019 15:55


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