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The Influence of Calcium Infiltration on the Sintering Behavior and Dissolution of Beta-Tricalcium Phosphate

Wei, Yiwen (2015) The Influence of Calcium Infiltration on the Sintering Behavior and Dissolution of Beta-Tricalcium Phosphate. Master's Thesis, University of Pittsburgh. (Unpublished)

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Beta-Tricalcium phosphate (β-TCP) has attracted attention as a scaffold material for bone tissue
engineering. The calcium content in β-TCP is thought to have an important influence on the
sintering and biodegradability of the scaffold and the growth of bone tissue. The aim of this thesis
was to process a β-TCP scaffold with enhanced solubility by infiltration of porous TCP with a
calcium salt. The sintering behavior and phase distribution of Ca infiltrated β-TCP was
investigated using relative density measurement, SEM observation and XRD analysis. High
temperature sintering was only able to achieve a relative density of 89% and showed evidence of
liquid phase formation consistent calcium deficient β-TCP. The liquid phase formation is thought
to have caused coarsening of the microstructure that limited the final density. Similar studies
were also conducted on Ca-infiltrated β-TCP. The results suggest that Ca-infiltration results in the
stabilization of α-TCP rather than the formation of significant amounts of other calcium rich
phases, which is thought to enhance degradation when the materials were immersed in water.
Additionally, β-TCP foam was successfully processed using an emulsion based direct foaming
method. Immersion of the foams in water showed no evidence of the enhanced degradation due to
calcium rich phases.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Wei, Yiwenyiw69@pitt.eduYIW690000-0001-6637-3393
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairNettleship, Iannettles@pitt.eduNETTLES
Committee MemberChmielus, Markuschmielus@pitt.eduCHMIELUS
Committee MemberLee, Jung-Kunjul37@pitt.eduJUL37
Date: 9 June 2015
Date Type: Publication
Defense Date: 1 April 2015
Approval Date: 9 June 2015
Submission Date: 3 April 2015
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 87
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Materials Science and Engineering
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Tissue engineering, Tricalcium phosphate, Scaffold,β-TCP
Date Deposited: 09 Jun 2015 13:17
Last Modified: 15 Nov 2016 14:26


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