Wei, Yiwen
(2015)
The Influence of Calcium Infiltration on the Sintering Behavior and Dissolution of Beta-Tricalcium Phosphate.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Beta-Tricalcium phosphate (β-TCP) has attracted attention as a scaffold material for bone tissue
engineering. The calcium content in β-TCP is thought to have an important influence on the
sintering and biodegradability of the scaffold and the growth of bone tissue. The aim of this thesis
was to process a β-TCP scaffold with enhanced solubility by infiltration of porous TCP with a
calcium salt. The sintering behavior and phase distribution of Ca infiltrated β-TCP was
investigated using relative density measurement, SEM observation and XRD analysis. High
temperature sintering was only able to achieve a relative density of 89% and showed evidence of
liquid phase formation consistent calcium deficient β-TCP. The liquid phase formation is thought
to have caused coarsening of the microstructure that limited the final density. Similar studies
were also conducted on Ca-infiltrated β-TCP. The results suggest that Ca-infiltration results in the
stabilization of α-TCP rather than the formation of significant amounts of other calcium rich
phases, which is thought to enhance degradation when the materials were immersed in water.
Additionally, β-TCP foam was successfully processed using an emulsion based direct foaming
method. Immersion of the foams in water showed no evidence of the enhanced degradation due to
calcium rich phases.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
9 June 2015 |
| Date Type: |
Publication |
| Defense Date: |
1 April 2015 |
| Approval Date: |
9 June 2015 |
| Submission Date: |
3 April 2015 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
87 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Materials Science and Engineering |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Tissue engineering, Tricalcium phosphate, Scaffold,β-TCP |
| Date Deposited: |
09 Jun 2015 13:17 |
| Last Modified: |
15 Nov 2016 14:26 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/24299 |
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